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Confirmation of region-specific patterns of gene expression in the human brain

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Abstract

The human brain is divided and categorized in different ways, yet a molecular genetic approach to region specificity does not exist. Using data from 12 healthy control subjects across 18 brain regions, we performed a microarray analysis using both the HG-U133AB and HG-U133 plus 2 chips for each subject to determine molecular targets showing region specificity. Using a previously published data as our guide, we confirm SIX3, GPR6, SH3RF2, and hSyn as molecular markers of the nucleus accumbens and gamma-aminobutyric-acid A receptor alpha-6, Nik-related kinase, and eomesodermin as molecular markers of the cerebellum.

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Acknowledgment

Carl Ernst and Adolfo Sequeira contributed equally to this work.

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Authors and Affiliations

  1. McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada

    Carl Ernst, Adolfo Sequeira, Tim Klempan & Gustavo Turecki

  2. Department of Computer Science, University of Toronto, Toronto, ON, Canada

    Neil Ernst

  3. Gene Logic, Inc, Gaithersburg, MD, USA

    Jarlath ffrench-Mullen

  4. Douglas Hospital Research Centre, Pavilion Frank B Common, Rm. F-3125, 6875 LaSalle Blvd., Verdun, Montreal, QC, H4H 1R3, Canada

    Gustavo Turecki

Authors
  1. Carl Ernst
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  2. Adolfo Sequeira
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  3. Tim Klempan
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  4. Neil Ernst
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  5. Jarlath ffrench-Mullen
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  6. Gustavo Turecki
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Corresponding author

Correspondence to Gustavo Turecki.

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10048_2007_84_MOESM1_ESM.doc

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Ernst, C., Sequeira, A., Klempan, T. et al. Confirmation of region-specific patterns of gene expression in the human brain. Neurogenetics 8, 219–224 (2007). https://doi.org/10.1007/s10048-007-0084-2

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  • DOI: https://doi.org/10.1007/s10048-007-0084-2

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