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A new locus for dominant hereditary spastic paraplegia maps to chromosome 2p12

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References

  1. Fink JK, Heiman-Patterson T, Bird T, Cambi F, Dube MP, Figlewicz DA, Haines JL, Hentati A, Pericak-Vance MA, Raskind W, Rouleau GA, Siddique T (1996) Hereditary spastic paraplegia: advances in genetic research. Hereditary Spastic Paraplegia Working group. [Review] [46 refs]. Neurology 46:1507–1514

    PubMed  CAS  Google Scholar 

  2. Reid E (2003) Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias. J Med Genet 40:81–86

    Article  PubMed  CAS  Google Scholar 

  3. Orlacchio A, Kawarai T, Gaudiello F, George-Hyslop PH, Floris R, Bernardi G (2005) New locus for hereditary spastic paraplegia maps to chromosome 1p31.1–1p21.1. Ann Neurol 58:423–429

    Article  PubMed  CAS  Google Scholar 

  4. Windpassinger C, Auer-Grumbach M, Irobi J, Patel H, Petek E, Horl G, Malli R, Reed JA, Dierick I, Verpoorten N, Warner TT, Proukakis C, Van den BP, Verellen C, Van Maldergem L, Merlini L, De Jonghe P, Timmerman V, Crosby AH, Wagner K (2004) Heterozygous missense mutations in BSCL2 are associated with distal hereditary motor neuropathy and Silver syndrome. Nat Genet 36:271–276

    Article  PubMed  CAS  Google Scholar 

  5. Ashley-Koch A, Bonner ER, Gaskell PC, West SG, Tim R, Wolpert CM, Jones R, Farrell CD, Nance M, Svenson IK, Marchuk DA, Boustany RM, Vance JM, Scott WK, Pericak-Vance MA (2001) Fine mapping and genetic heterogeneity in the pure form of autosomal dominant familial spastic paraplegia. Neurogenetics 3:91–97

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

We would like to thank the families for their participation and the support personnel from the Center for Human Genetics at Duke. This work was supported by a grant from NINDS to MPV (NS26630).

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Authors and Affiliations

  1. Center for Human Genetics, Duke University Medical Center, Durham, NC, USA

    Stephan Züchner, Melanie E. Kail, Perry C. Gaskell, Margaret A. Pericak-Vance & Allison E. Ashley-Koch

  2. Department for Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC, USA

    Stephan Züchner

  3. Park Nicollet Clinic, Minneapolis, MN, USA

    Martha A. Nance

  4. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA

    Ingrid K. Svenson & Douglas A. Marchuk

  5. DUMC, 595 LaSalle St., P.O. BOX 3445, Durham, NC, 27710, USA

    Stephan Züchner

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  1. Stephan Züchner
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  2. Melanie E. Kail
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  7. Margaret A. Pericak-Vance
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  8. Allison E. Ashley-Koch
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Correspondence to Stephan Züchner.

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Züchner, S., Kail, M.E., Nance, M.A. et al. A new locus for dominant hereditary spastic paraplegia maps to chromosome 2p12. Neurogenetics 7, 127–129 (2006). https://doi.org/10.1007/s10048-006-0029-1

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  • DOI: https://doi.org/10.1007/s10048-006-0029-1

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