Abstract
Hemophilia B is caused by a deficit or decreased activity of factor IX. Mutation in factor IX is made up of a majority of amino acid substitutions. We examined the relation between the activation level of factor IX and the category of amino acid substitution with regression analysis. As parameters, we used four physical-chemical parameters of amino acids and Dayhoff’s PAM matrix. In addition, the average of the activation level with the same amino acid substitution was used for the analysis. We analyzed the relationship between variations containing cysteine or factor IX’s seven regions and activity levels.
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Furutani H (1995) A method to estimate effects of amino acid substitutions in blood coagulation factor IX from hemophilia B patients. Proceedings of MEDINFO 95, Vancouver, p 909
Furutani H (1993) Analysis of correlation between amino acid substitution and factor IX activity in hemophilia B (in Japanese). Iryoujouhougaku 13(4):211–220
Yoshitake S, Schach BG, Foster DC, et al (1985) Nucleotide sequence of the gene for human factor IX. Biochemistry 24: 3736–3750
Giannelli F, Green PM, High KA, et al (1991) Haemophilia B: database of point mutations and short additions, 2nd edn. Nucleic Acids Research, vol 19,suppl, pp 2193–2196
fixhome: http://www.kcl.ac.uk/ip/petergreen/haemBdatabase.html
Weir BS (1996) Genetic data analysis, II. Sinauer, MA
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This work was presented in part at the 13th International Symposium on Artificial Life and Robotics, Oita, Japan, January 31–February 2, 2008
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Utsunomiya, M., Sakamoto, M. & Furutani, H. Regression analysis of amino acid substitutions and factor IX activity in hemophilia B. Artif Life Robotics 13, 531–534 (2009). https://doi.org/10.1007/s10015-008-0600-y
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DOI: https://doi.org/10.1007/s10015-008-0600-y