Skip to main content
SpringerLink
Log in

Rapid progression of rhabdoid components of a composite high-grade glioma and rhabdoid tumor in the occipital lobe of an adult

  • Case Report
  • Published:
Brain Tumor Pathology Aims and scope Submit manuscript

An Erratum to this article was published on 26 February 2012

Abstract

We report a very unusual case of a composite high-grade glioma and rhabdoid tumor in an adult. A 22-year-old woman presented with scintillating scotoma due to a solid tumor with surrounding brain edema in the right occipital lobe. The tumor was grossly resected. Histological examinations showed that the tumor was mainly composed of INI1-positive high-grade glioma tissue containing an INI1-negative rhabdoid component. She received radiation therapy and chemotherapy. Three months after the surgery, she again complained of visual disturbances, and tumor recurrence within the resection cavity was noted. A second operation was performed. The findings of histological examinations of the surgical specimen obtained during the second surgery were completely different from those of the specimen obtained during the initial surgery. Only the rhabdoid component showed remarkable proliferation and did not express INI1. Diffuse dissemination along the craniospinal axis eventually progressed, and she died 5 months after the initial diagnosis. We suggest that the inactivation of the INI1 gene affects potent proliferation activity and resistance to both chemotherapy and radiation therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Beckwith JB, Palmer NF (1978) Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study. Cancer 41:1937–1948

    Article  PubMed  CAS  Google Scholar 

  2. Weeks DA, Beckwith JB, Mierau GW, Luckey DW (1989) Rhabdoid tumor of kidney. A report of 111 cases from the National Wilms’ Tumor Study Pathology Center. Am J Surg Pathol 13:439–458

    Article  PubMed  CAS  Google Scholar 

  3. Rorke LB, Packer RJ, Biegel JA (1996) Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. J Neurosurg 85:56–65

    Article  PubMed  CAS  Google Scholar 

  4. Rorke LB, Packer R, Biegel J (1995) Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood. J Neurooncol 24:21–28

    Article  PubMed  CAS  Google Scholar 

  5. Burger PC, Yu IT, Tihan T, Friedman HS, Strother DR, Kepner JL, Duffner PK, Kun LE, Perlman EJ (1998) Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study. Am J Surg Pathol 22:1083–1092

    Article  PubMed  CAS  Google Scholar 

  6. White FV, Dehner LP, Belchis DA, Conard K, Davis MM, Stocker JT, Zuppan CW, Biegel JA, Perlman EJ (1999) Congenital disseminated malignant rhabdoid tumor: a distinct clinicopathologic entity demonstrating abnormalities of chromosome 22q11. Am J Surg Pathol 23:249–256

    Article  PubMed  CAS  Google Scholar 

  7. Sajedi M, Wolff JE, Egeler RM, Pinto A, Hughes R, Anderson RA, Coppes MJ (2002) Congenital extrarenal non-central nervous system malignant rhabdoid tumor. J Pediatr Hematol Oncol 24:316–320

    Article  PubMed  Google Scholar 

  8. Hilden JM, Meerbaum S, Burger P, Finlay J, Janss A, Scheithauer BW, Walter AW, Rorke LB, Biegel JA (2004) Central nervous system atypical teratoid/rhabdoid tumor: results of therapy in children enrolled in a registry. J Clin Oncol 22:2877–2884

    Article  PubMed  Google Scholar 

  9. Judkins AR, Mauger J, Ht A, Rorke LB, Biegel JA (2004) Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms. Am J Surg Pathol 28:644–650

    Article  PubMed  Google Scholar 

  10. Hoot AC, Russo P, Judkins AR, Perlman EJ, Biegel JA (2004) Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors. Am J Surg Pathol 28:1485–1491

    Article  PubMed  Google Scholar 

  11. Perry A, Fuller CE, Judkins AR, Dehner LP, Biegel JA (2005) INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas. Mod Pathol 18:951–958

    Article  PubMed  CAS  Google Scholar 

  12. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996

    Article  PubMed  CAS  Google Scholar 

  13. Meis JM, Ho KL, Nelson JS (1990) Gliosarcoma: a histologic and immunohistochemical reaffirmation. Mod Pathol 3:19–24

    PubMed  CAS  Google Scholar 

  14. Maruno M, Ghulam Muhammad AK, Taguchi J, Suzuki T, Wada K, Isaka T, Yoshimine T (2006) Giant cell type of primary intracranial malignant fibrous histiocytoma: a case report. Brain Tumor Pathol 23:65–70

    Article  PubMed  Google Scholar 

  15. Galloway M (2010) CD34 expression in glioblastoma and giant cell glioblastoma. Clin Neuropathol 29:89–93

    PubMed  CAS  Google Scholar 

  16. Cai N, Kahn LB (2004) A report of primary brain fibrosarcoma with literature review. J Neurooncol 68:161–167

    Article  PubMed  Google Scholar 

  17. Montgomery P, Kuhn JP, Berger PE (1985) Rhabdoid tumor of the kidney: a case report. Urol Radiol 7:42–44

    Article  PubMed  CAS  Google Scholar 

  18. Judkins AR, Ellison DW (2010) Atypical teratoid/rhabdoid tumour. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system. IARC Press, Lyon, pp 147–149

    Google Scholar 

  19. Takahashi K, Nishihara H, Katoh M, Yoshinaga T, Mahabir R, Kanno H, Kimura T, Tanino M, Ikeda J, Sawamura Y, Nagashima K, Tanaka S (2010) A case of atypical teratoid/rhabdoid tumor in an adult, with long survival. Brain Tumor Pathol 28:71–76

    Google Scholar 

  20. Horn M, Schlote W, Lerch KD, Steudel WI, Harms D, Thomas E (1992) Malignant rhabdoid tumor: primary intracranial manifestation in an adult. Acta Neuropathol 83:445–448

    Article  PubMed  CAS  Google Scholar 

  21. Cossu A, Massarelli G, Manetto V, Viale G, Tanda F, Bosincu L, Iuzzolino P, Cossu S, Padovani R, Eusebi V (1993) Rhabdoid tumours of the central nervous system. Report of three cases with immunocytochemical and ultrastructural findings. Virchows Arch A Pathol Anat Histopathol 422:81–85

    Article  PubMed  CAS  Google Scholar 

  22. Fisher BJ, Siddiqui J, Macdonald D, Cairney AE, Ramsey D, Munoz D, Del Maestro R (1996) Malignant rhabdoid tumor of brain: an aggressive clinical entity. Can J Neurol Sci 23:257–263

    PubMed  CAS  Google Scholar 

  23. Ashraf R, Bentley RC, Awan AN, McLendon RE, Ragozzino MW (1997) Implantation metastasis of primary malignant rhabdoid tumor of the brain in an adult (one case report). Med Pediatr Oncol 28:223–227

    Article  PubMed  CAS  Google Scholar 

  24. Byram DA (2000) Leadership: a skill, not a role. AACN Clin Issues 11:463–469

    Article  PubMed  CAS  Google Scholar 

  25. Sugita Y, Takahashi Y, Hayashi I, Morimatsu M, Okamoto K, Shigemori M (1999) Pineal malignant rhabdoid tumor with chondroid formation in an adult. Pathol Int 49:1114–1118

    Article  PubMed  CAS  Google Scholar 

  26. Kuge A, Kayama T, Tsuchiya D, Kawakami K, Saito S, Nakazato Y, Suzuki H (2000) Suprasellar primary malignant rhabdoid tumor in an adult: a case report. No Shinkei Geka 28:351–358

    PubMed  CAS  Google Scholar 

  27. Arrazola J, Pedrosa I, Mendez R, Saldana C, Scheithauer BW, Martinez A (2000) Primary malignant rhabdoid tumour of the brain in an adult. Neuroradiology 42:363–367

    Article  PubMed  CAS  Google Scholar 

  28. Lutterbach J, Liegibel J, Koch D, Madlinger A, Frommhold H, Pagenstecher A (2001) Atypical teratoid/rhabdoid tumors in adult patients: case report and review of the literature. J Neurooncol 52:49–56

    Article  PubMed  CAS  Google Scholar 

  29. Bruch LA, Hill DA, Cai DX, Levy BK, Dehner LP, Perry A (2001) A role for fluorescence in situ hybridization detection of chromosome 22q dosage in distinguishing atypical teratoid/rhabdoid tumors from medulloblastoma/central primitive neuroectodermal tumors. Hum Pathol 32:156–162

    Article  PubMed  CAS  Google Scholar 

  30. Pimentel J, Silva R, Pimentel T (2003) Primary malignant rhabdoid tumors of the central nervous system: considerations about two cases of adulthood presentation. J Neurooncol 61:121–126

    Article  PubMed  Google Scholar 

  31. Kachhara R, Retnam TM, Kumar S, Nair S, Bhattacharya RN, Krishnamoorthy T, Radhakrishnan VV (2003) Rhabdoid tumor of the thalamus. Neurol India 51:273–274

    PubMed  CAS  Google Scholar 

  32. Kawaguchi T, Kumabe T, Watanabe M, Tominaga T (2004) Atypical teratoid/rhabdoid tumour with leptomeningeal dissemination in an adult. Acta Neurochir (Wien) 146:1033–1038 (discussion 1038)

    Article  CAS  Google Scholar 

  33. Erickson ML, Johnson R, Bannykh SI, de Lotbiniere A, Kim JH (2005) Malignant rhabdoid tumor in a pregnant adult female: literature review of central nervous system rhabdoid tumors. J Neurooncol 74:311–319

    Article  PubMed  Google Scholar 

  34. Raisanen J, Biegel JA, Hatanpaa KJ, Judkins A, White CL, Perry A (2005) Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults. Brain Pathol 15:23–28

    Article  PubMed  CAS  Google Scholar 

  35. Chen YW, Wong TT, Ho DM, Huang PI, Chang KP, Shiau CY, Yen SH (2006) Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience). Int J Radiat Oncol Biol Phys 64:1038–1043

    Article  PubMed  Google Scholar 

  36. Rezanko T, Tunakan M, Kahraman A, Sucu HK, Gelal F, Akkol I (2006) Primary rhabdoid tumor of the brain in an adult. Neuropathology 26:57–61

    Article  PubMed  Google Scholar 

  37. Ingold B, Moschopulos M, Hutter G, Seeger H, Rothlisberger B, Landolt H, Yonekawa Y, Jochum W, Heppner FL (2006) Abdominal seeding of an atypical teratoid/rhabdoid tumor of the pineal gland along a ventriculoperitoneal shunt catheter. Acta Neuropathol 111:56–59

    Article  PubMed  Google Scholar 

  38. Chacko G, Chacko AG, Dunham CP, Judkins AR, Biegel JA, Perry A (2007) Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. J Neurooncol 84:217–222

    Article  PubMed  Google Scholar 

  39. Zarovnaya EL, Pallatroni HF, Hug EB, Ball PA, Cromwell LD, Pipas JM, Fadul CE, Meyer LP, Park JP, Biegel JA, Perry A, Rhodes CH (2007) Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature. J Neurooncol 84:49–55

    Article  PubMed  Google Scholar 

  40. Arita K, Sugiyama K, Sano T, Oka H (2008) Atypical teratoid/rhabdoid tumour in sella turcica in an adult. Acta Neurochir (Wien) 150:491–495 discussion 496

    Article  CAS  Google Scholar 

  41. Makuria AT, Rushing EJ, McGrail KM, Hartmann DP, Azumi N, Ozdemirli M (2008) Atypical teratoid rhabdoid tumor (AT/RT) in adults: review of four cases. J Neurooncol 88:321–330

    Article  PubMed  Google Scholar 

  42. Samaras V, Stamatelli A, Samaras E, Stergiou I, Konstantopoulou P, Varsos V, Judkins AR, Biegel JA, Barbatis C (2009) Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient. Clin Neuropathol 28:1–10

    PubMed  CAS  Google Scholar 

  43. Takei H, Adesina AM, Mehta V, Powell SZ, Langford LA (2010) Atypical teratoid/rhabdoid tumor of the pineal region in an adult. J Neurosurg 113:374–379

    Article  PubMed  Google Scholar 

  44. Allen JC, Judkins AR, Rosenblum MK, Biegel JA (2006) Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: case study. Neuro Oncol 8:79–82

    Article  PubMed  Google Scholar 

  45. Rodriguez FJ, Scheithauer BW, Giannini C, Bryant SC, Jenkins RB (2008) Epithelial and pseudoepithelial differentiation in glioblastoma and gliosarcoma: a comparative morphologic and molecular genetic study. Cancer 113:2779–2789

    Article  PubMed  Google Scholar 

  46. Momota H, Iwami K, Fujii M, Motomura K, Natsume A, Ogino J, Hasegawa T, Wakabayashi T (2011) Rhabdoid glioblastoma in a child: case report and literature review. Brain Tumor Pathol 28:65–70

    Article  PubMed  Google Scholar 

  47. Wyatt-Ashmead J, Kleinschmidt-DeMasters BK, Hill DA, Mierau GW, McGavran L, Thompson SJ, Foreman NK (2001) Rhabdoid glioblastoma. Clin Neuropathol 20:248–255

    PubMed  CAS  Google Scholar 

  48. Lath R, Unosson D, Blumbergs P, Stahl J, Brophy BP (2003) Rhabdoid glioblastoma: a case report. J Clin Neurosci 10:325–328

    Article  PubMed  Google Scholar 

  49. Kleinschmidt-DeMasters BK, Alassiri AH, Birks DK, Newell KL, Moore W, Lillehei KO (2010) Epithelioid versus rhabdoid glioblastomas are distinguished by monosomy 22 and immunohistochemical expression of INI-1 but not claudin 6. Am J Surg Pathol 34:341–354

    Article  PubMed  Google Scholar 

  50. Fung KM, Perry A, Payner TD, Shan Y (2004) Rhabdoid glioblastoma in an adult. Pathology 36:585–587

    Article  PubMed  Google Scholar 

  51. Akimoto J, Namatame H, Haraoka J, Kudo M (2005) Epithelioid glioblastoma: a case report. Brain Tumor Pathol 22:21–27

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan

    Junkoh Yamamoto, Mayu Takahashi, Yoshiteru Nakano, Yoshiteru Soejima, Takeshi Saito, Daisuke Akiba & Shigeru Nishizawa

  2. Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Junko Hirato & Yoichi Nakazato

Authors
  1. Junkoh Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mayu Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshiteru Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiteru Soejima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takeshi Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Daisuke Akiba
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Junko Hirato
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yoichi Nakazato
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Shigeru Nishizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Junkoh Yamamoto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamamoto, J., Takahashi, M., Nakano, Y. et al. Rapid progression of rhabdoid components of a composite high-grade glioma and rhabdoid tumor in the occipital lobe of an adult. Brain Tumor Pathol 29, 113–120 (2012). https://doi.org/10.1007/s10014-011-0069-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10014-011-0069-6

Keywords

Search

Navigation