Abstract
Carbon ionic liquid electrode (CILE) was used as a substrate for immobilization and determination of amoxicillin (AMX) in phosphate buffer solution. The electrochemical response of AMX showed an irreversible oxidation peak in the first scan and redox peaks corresponding to the electrooxidation of product in the subsequent scans which gradually grew upon repetitive scanning. Effect of experimental conditions on electrooxidation of AMX and its adsorbed intermediates was investigated, and possible mechanism for strong immobilization is suggested. The electrode response was linear in the concentration range of 5.0 to 400.0 μmol L−1 AMX with a detection limit of 0.8 μmol L−1 AMX. There was no serious interference from other β-lactam family of antibiotics such as ampicillin and penicillin. The electrode showed good selectivity as well as high sensitivity toward quantification of AMX in pharmaceuticals and urine samples.
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References
Finch RG, Greenwood D, Norrby SR, Whitley RJ (2003) Antibiotics and chemotherapy: anti-infective agents and their use in therapy. Churchill Livingstone, Edinburgh
Hitner H, Nagle B (2005) Pharmacology: an introduction. McGraw Hill, New York
Prescott JF, Baggot JD, Walker RD (2000) Antimicrobial therapy in veterinary medicine. Iowa State University Press, Ames
Plumb DC (2005) Veterinary drug handbook. Blackwell Publishing, Ames
Remers WA, Delagado JN (1998) Textbook on organic medicinal and pharmaceutical chemistry. Lippincott-Raven Publishers, New York
Goodman-Hillman A, Rall T, Nier A, Taylor P (1996) The pharmacological basis of therapeutics. McGraw Hill, New York
Benito-Pena E, Urraca JL, Moreno-Bondi MC (2009) J Pharm Biomed Anal 49:289–294
Dousa M, Hosmanova R (2005) J Pharm Biomed Anal 37:373–377
Liu H, Wang H, Sunderland VB (2005) J Pharm Biomed Anal 37:395–398
De Baere S, De Backer P (2007) Anal Chim Acta 586:319–325
Hernandez M, Borrull F, Calull M (1999) J Chromatogr B 731:309–315
Garcia-Reiriz A, Damiani PC, Olivieri AC (2007) Talanta 71:806–815
Rojanarata T, Opanasopita P, Ngawhirunpat T, Saehuan C, Wiyakrutta S, Meevootisom V (2010) Enzym Microb Technol 46:292–296
Hasanpour F, Ensafi AA, Khayamian T (2010) Anal Chim Acta 670:44–50
Rezaei B, Damiri S (2009) Electroanalysis 21:1577–1585
Kumar AS, Sornambikai S, Deepika L, Zen JM (2010) J Mater Chem 20:10152–10158
Santos DP, Bergamini MF, Zanoni MVB (2008) Sensors Actuators B 133:398–403
Fouladgar M, Hadjmohammadi MR, Khalilzadeh MA, Biparva P, Teymoori N, Beitollahi H (2011) Int J Electrochem Sci 6:1355–1366
Ojani R, Raoof J, Zamani S (2012) Bioelectrochemistry 85:44–49
Uslu B, Biryol I (1999) J Pharm Biomed Anal 20:59–598
Safavi A, Maleki N, Moradlou O (2008) Electroanalysis 20:2158–2162
Maleki N, Safavi A, Tajabadi F (2007) Electroanalysis 19:2247–2250
Safavi A, Maleki N, Moradlou O, Tajabadi F (2006) Anal Biochem 359:224–229
Safavi A, Maleki N, Tajabadi F (2007) Analyst 132:54–58
Safavi A, Maleki N, Ershadifar H, Tajabadi F (2010) Anal Chim Acta 674:176–181
Absalan G, Akhond M, Ershadifar H (2015) J Solid State Electrochem 19:1113–1121
Maleki N, Safavi A, Tajabadi F (2006) Anal Chem 78:3820–3826
Chun S, Dzyuba SV, Bartsch RA (2001) Anal Chem 73:3737–3741
Shahrokhian S, Hosseini-Nassab N, Kamalzadeh Z (2014) J Solid State Electrochem 18:77–88
Gattrell M, Kirk DW (1993) J Electrochem Soc 140:1534–1540
Yang X, Kirsch J, Fergus J, Simonian A (2013) Electrochim Acta 94:259–268
Enache TA, Oliveira-Brett AM (2011) J Electroanal Chem 55:9–16
Mathiyarasu J, Joseph J, Phani KLN, Yegnaraman V (2004) Indian J Chem Technol 11:797–803
Wang J, Dea RP, Musameh M (2003) Electroanalysis 15:1830–1834
Putra EK, Pranowo R, Sunarso J, Indraswati N, Ismadji S (2009) Water Res 43:2419–2430
Bard AJ, Faulkner LR (2001) Electrochemical methods: fundamentals and applications. Wiley, New York
Wang J (2001) Analytical electrochemistry. Wiley, New York
Kissinger PT, Heineman WR (1996) Laboratory techniques in electroanalytical chemistry. Marcel Dekker Inc, New York
Salimi A, Hallaj R, Mamkhezri H, Hosaini SMT (2008) J Electroanal Chem 619–620:31–38
Laviron E (1979) J Electroanal Chem 101:19–28
Ingle JD, Crouch SR (1988) Spectrochemical analysis. Prentice-Hall Inc, USA
Bergamini MF, Teixeira MFS, Dockal ER, Bocchi N, Cavalheiro ETG (2006) J Electrochem Soc 153:E94–E98
Shafieyan H, Rouhollahi A (2010) Anal Bioanal Electrochem 2:13–23
Brahman PK, Dar RA, Pitre KS (2013) Sensors Actuators B 176:307–314
Kurniawan F, Tsakova V, Mirsky VM (2006) Electroanalysis 18:1937–1942
Kar A (2005) Pharmaceutical drug analysis. New Age International Publisher, New Delhi
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A grateful acknowledgment is made to Shiraz University Research Council for supporting this research.
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Absalan, G., Akhond, M. & Ershadifar, H. Highly sensitive determination and selective immobilization of amoxicillin using carbon ionic liquid electrode. J Solid State Electrochem 19, 2491–2499 (2015). https://doi.org/10.1007/s10008-015-2894-8
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DOI: https://doi.org/10.1007/s10008-015-2894-8