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Efficient electrocatalytic oxidation and selective determination of isoniazid by Fe(tmphen) 2+3 -exchanged Nafion®-modified electrode

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Abstract

Cyclic voltammetry and electrochemical impedance studies of Fe(tmphen) 2+3 (where tmphen = 3,4,7,8-tetramethyl-1,10-phenanthroline)-immobilized Nafion®-modified glassy carbon electrode (GC/Nf/Fe(tmphen) 2+3 ) are carried out in 0.1 M Na2SO4 solution. Nafion–Fe(tmphen) 2+3 complex exhibits efficient electrocatalytic oxidation of isoniazid. The linear double reciprocal plot of current and concentration of isoniazid shows a Michaelis–Menten-type catalytic process. The catalytic oxidation currents are proportional to the concentration of isoniazid and show a wide linear calibration range for the quantitative determination of isoniazid. Detection limit and sensitivity are found to be 13 μM and 2.5 μA mM−1, respectively.

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Acknowledgments

Generous funding from DST and CSIR, New Delhi is gratefully acknowledged. We acknowledge Dr. S. Abraham John, Gandhigram Rural University, India, for fruitful discussions. One of the authors, UPA, acknowledges CSIR for SRF.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India

    Uday Pratap Azad & Vellaichamy Ganesan

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  1. Uday Pratap Azad
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  2. Vellaichamy Ganesan
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Correspondence to Vellaichamy Ganesan.

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Azad, U.P., Ganesan, V. Efficient electrocatalytic oxidation and selective determination of isoniazid by Fe(tmphen) 2+3 -exchanged Nafion®-modified electrode. J Solid State Electrochem 16, 2907–2911 (2012). https://doi.org/10.1007/s10008-012-1724-5

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  • DOI: https://doi.org/10.1007/s10008-012-1724-5

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