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Electrochemical sensor using glassy carbon electrode modified with acylpyrazolone-multiwalled carbon nanotube composite film for determination of xanthine

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Abstract

In this work, an electrochemical sensor 1-phenyl-3-methyl-4-(2-furoyl)-5-pyrazolone/multiwalled carbon nanotubes/glassy carbon electrode (GCE) was prepared for the determination of xanthine (XN) in the presence of an excess of uric acid. Cyclic voltammetry and differential pulse voltammetry were used to characterize the electrode. The oxidation of XN occurred in a well-defined peak having E p 0.73 V in phosphate buffer solution of pH 6.0. Compared with the bare GCE, the electrochemical sensor greatly enhanced the oxidation signal of XN with negative shift in peak potential about 110 mV. Based on this, a sensitive, rapid, and convenient electrochemical method for the determination of XN has been proposed. Under the optimized conditions, the oxidation peak current of XN was found to be proportional to its concentration in the range of 0.3~50 μM with a detection limit of 0.08 μM. The analytical utility of the proposed method was demonstrated by the direct assay of XN in urine samples and was found to be promising at our preliminary experiments.

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Acknowledgment

This work was supported by grants from the Nature Science Foundation of Heilongjiang Province, People's Republic of China (No. B201004) and the Scientific and Technical Development Foundation of Harbin Normal University (No. 08XYG-12).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, People’s Republic of China

    Yun Song & Jinzhou Li

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  1. Yun Song
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  2. Jinzhou Li
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Correspondence to Jinzhou Li.

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Song, Y., Li, J. Electrochemical sensor using glassy carbon electrode modified with acylpyrazolone-multiwalled carbon nanotube composite film for determination of xanthine. J Solid State Electrochem 16, 689–695 (2012). https://doi.org/10.1007/s10008-011-1419-3

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  • DOI: https://doi.org/10.1007/s10008-011-1419-3

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