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The role of leukocyte and platelet-rich fibrin in the prevention of medication-related osteonecrosis of the jaw, in patients requiring dental extractions: an observational study

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Abstract

Purpose

Medication-related osteonecrosis of the jaw (MRONJ) is a significant complication which can present following a dental extraction in patients receiving anti-resorptive and anti-angiogenic medications. The purpose of this study was to investigate the possible beneficial effect of L-PRF in the prevention of MRONJ in patients receiving these medications and requiring dental extractions.

Methods

Thirty-nine patients were included and divided into two groups, depending on whether L-PRF was used after the required dental extraction or not. Subsequently, the patients were categorised into low and high-risk for developing MRONJ, as recommended by the SDCEP guidance.

Results

None of the patients in the L-PRF group returned with established MRONJ. Five high-risk patients in the control group presented with established MRONJ in the follow-up appointment. A significant statistical difference (p = 0.04) was observed following a comparison of the high-risk patients of the two groups.

Conclusion

These encouraging results suggest that L-PRF may be useful in the prevention of MRONJ following a dental extraction especially in patients of the higher risk category. A protocol for the management of this type of patients is also introduced.

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Data availability

The data that support the findings of this study are available from the corresponding author, PP, upon reasonable request.

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Author notes

  1. Eleni Besi

    Present address: Oral Surgery Department, Queen Mary University, Barts and the London School of Medicine and Dentistry, Turner Street, London, E1 2AD, UK

Authors and Affiliations

  1. Oral Surgery Department, Edinburgh Dental Institute, University of Edinburgh, Lauriston Building, Lauriston Place, Edinburgh, EH3 9HA, UK

    Eleni Besi & Panagiotis Pitros

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Contributions

E.B and P.P contributed equally in writing the manuscript and preparation of figures and tables. All authors reviewed the manuscript.

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Correspondence to Panagiotis Pitros.

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This study has received approval from the Oral Health Service, Quality Improvement Team of NHS Lothian.

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The authors declare no competing interests.

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Besi, E., Pitros, P. The role of leukocyte and platelet-rich fibrin in the prevention of medication-related osteonecrosis of the jaw, in patients requiring dental extractions: an observational study. Oral Maxillofac Surg (2024). https://doi.org/10.1007/s10006-023-01204-z

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