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Opioid requirement and pain intensity after mandibular surgeries with dexmedetomidine administration in two ways: intraoperative infusion versus bolus injection

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Oral and Maxillofacial Surgery Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study is to compare the opioid requirement and pain intensity after surgeries of mandibular fractures with administration of dexmedetomidine by two approaches of infusion and single bolus.

Methods

In this double-blind clinical trial, the participants were randomized and matched in terms of age and gender in two groups (infusion and bolus). In both groups, the amount of narcotic used, hemodynamic indices, oxygen saturation, and pain intensity were collected based on the ten-point Visual Analogue Scale (VAS) at 7 time points for 24 h. SPSS version 24 software was used for data analysis. A significance level of less than 5% was considered.

Results

A total of 40 patients were included in the study. There was no significant difference between the two groups in terms of gender, age, ASA class, and duration of surgery (P>0.05). There was no significant difference between the two groups in terms of nausea and vomiting and subsequently receiving anti-nausea medication (P>0.05). The need for opioid consumption after surgery was not different in two groups (P>0.05). Infusion of dexmedetomidine reduced postoperative pain more rapidly than its single bolus dose (P<0.05). However, over time, there was no significant difference between the two groups in terms of changes in oxygen saturation variables (P>0.05). Homodynamic indices including heart rate, systolic blood pressure, and diastolic blood pressure in the bolus group were significantly lower than the infusion group (P<0.05).

Conclusion

Administration of dexmedetomidine in the form of infusion can reduce postoperative pain better than bolus injection, with less probability of hypotension and bradycardia.

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Data availability

Data available on request from the authors

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Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

    Saeed Nezafati, Reza Khorshidi Khiavi, Ali Mortazavi & Loghman Ebrahimi

  2. Department of Anestheliology, Imam Reza Medical Research and Training Hospital, Tabriz, Iran

    Abbas Ali Dehghani

Authors
  1. Saeed Nezafati
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  2. Abbas Ali Dehghani
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  3. Reza Khorshidi Khiavi
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  4. Ali Mortazavi
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  5. Loghman Ebrahimi
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Contributions

All authors contributed to the study conception and design. Material preparation was performed by Saeed Nezafati, Loghman Ebrahimi, and Abbas Ali Dehghani. Data collection and analysis were done by Reza Khorshidi Khiavi, Ali Mortazavi, and Saeed Nezafati. Loghman Ebrahimi wrote the first draft of the manuscript, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Loghman Ebrahimi.

Ethics declarations

Ethics approval

This research has been approved by the ethics committee of Tabriz University of Medical Sciences (IR.TBZMED.REC.1401.308).

Consent to participate

Informed consent to participate in the study was obtained from all patients before the procedures.

Consent for publication

All the authors of this manuscript declare their consent for publication in “Oral and Maxillofacial Surgery.”

Conflict of interest

The authors declare no competing interests.

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Nezafati, S., Dehghani, A.A., Khiavi, R.K. et al. Opioid requirement and pain intensity after mandibular surgeries with dexmedetomidine administration in two ways: intraoperative infusion versus bolus injection. Oral Maxillofac Surg (2023). https://doi.org/10.1007/s10006-023-01169-z

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  • DOI: https://doi.org/10.1007/s10006-023-01169-z

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