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What do error patterns in processing facial expressions, social interaction scenes and vocal prosody tell us about the way social cognition works in children with 22q11.2DS?

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Abstract

Impairments in social cognition have been frequently described in 22q11.2 deletion syndrome (22q11.2DS) and are thought to be a hallmark of difficulties in social interactions. The present study addresses aspects that are critical for everyday social cognitive functioning but have received little attention so far. Sixteen children with 22q11.2DS and 22 controls completed 1 task of facial expression recognition, 1 task of attribution of facial expressions to faceless characters involved in visually presented social interactions, and 1 task of attribution of facial expressions to characters involved in aurally presented dialogues. All three tasks have in common to involve processing of emotions. All participants also completed two tasks of attention and two tasks of visual spatial perception, and their parents completed some scales regarding behavioural problems of their children. Patients performed worse than controls in all three tasks of emotion processing, and even worse in the second and third tasks. However, they performed above chance level in all three tasks, and the results were independent of IQ, age and gender. The analysis of error patterns suggests that patients tend to coarsely categorize situations as either attractive or repulsive and also that they have difficulties in differentiating emotions that are associated with threats. An isolated association between the tasks of emotion and behaviour was found, showing that the more frequently patients with 22q11.2DS perceive happiness where there is not, the less they exhibit aggressive behaviour.

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Acknowledgements

This study benefited from funding support from the LABEX CORTEX (ANR-11-LABX-0042) of the University of Lyon, under the “Investissements d’ Avenir” programme (ANR-11-IDEX-0007) run by the French National Research Agency (ANR). The authors are grateful to Maité Delgado for the production and adaptation of all stimuli of the three emotion tasks used in the present study. Many thanks to Margaux Vurpas for preparing and conducting the pilot study.

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Authors and Affiliations

  1. GénoPsy, Reference Center for Rare Diseases, Le Vinatier Hospital, 95 Bd Pinel, Bron, France

    Elodie Peyroux, Marie-Noëlle Babinet, Costanza Cannarsa, Emilie Favre & Caroline Demily

  2. EDRPsy, UMR 5229, CNRS, 67 Bd Pinel, Bron, France

    Elodie Peyroux, Marie-Noëlle Babinet, Costanza Cannarsa, Emilie Favre & Caroline Demily

  3. Université de Lyon, Lyon, France

    Costanza Cannarsa, Charline Madelaine & George A. Michael

  4. Laboratoire D’Étude Des Mécanismes Cognitifs (EA 3082), Université Lumière Lyon 2, Lyon, France

    Costanza Cannarsa, Charline Madelaine & George A. Michael

  5. Laboratoire de Psychologie de Caen Normandie PALM (EA 7452), Université Caen-Normandie, Caen, France

    Charline Madelaine

Authors
  1. Elodie Peyroux
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  2. Marie-Noëlle Babinet
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Corresponding author

Correspondence to George A. Michael.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was conducted in accordance with the Declaration of Helsinki and was approved by the local Ethics Committee (CPP Lyon-Sud Est IV, No. 15/041; ANSM, No. 2017-A00881-52; NCT03284060).

Informed consent

Informed written consent was obtained from all children and from their parents (or legal guardians).

Data repository

The data can be found at https://recherche.univ-lyon2.fr/etmeco/data/Peyroux-22q11-Data.zip.

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Peyroux, E., Babinet, MN., Cannarsa, C. et al. What do error patterns in processing facial expressions, social interaction scenes and vocal prosody tell us about the way social cognition works in children with 22q11.2DS?. Eur Child Adolesc Psychiatry 29, 299–313 (2020). https://doi.org/10.1007/s00787-019-01345-1

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  • DOI: https://doi.org/10.1007/s00787-019-01345-1

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