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A randomized triple-blind crossover trial of a hydrocolloid-containing dentifrice as a controlled-release system for fluoride

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Abstract

Objective

To evaluate retention of intraoral fluoride in biofilm and saliva, an experimental dentifrice containing hydrocolloid (tara gum) was used as a controlled-release system for fluoride (F).

Materials and methods

In a triple-blind randomized crossover trial with washout, 18 individuals used the following different dentifrices for a week: 100-TGF (sodium fluoride NaF associated with tara gum, 1100 mg/L), 50-TGF (50% NaF associated with tara gum + 50% free NaF, 1100 mg/L), PC (free NaF, 1100 mg/L), TG (with tara gum and without F), and placebo (without F or tara gum). On the seventh day of dentifrice use, biofilm was collected at 1 and 12 h, and saliva was collected up to 60 min and 12 h after the last toothbrushing. F concentrations were determined by physico-chemical analysis of fluoride using the hexamethyldisiloxane-facilitated diffusion technique. Data were subjected to two-way analysis of variance (repeated measures) and Spearman’s correlation coefficient (p < 0.05) testing.

Results

No significant difference was observed with the same dentifrice regarding F retention in biofilm at 1 and 12 h after toothbrushing for the 100-TGF, placebo, and TG groups (p > 0.05). The highest area under the curve values in saliva were found for the 50-TGF, 100-TGF, and PC groups.

Conclusion

The dentifrice containing hydrocolloid as a controlled-release system for F promoted F retention in the oral cavity, even at 12 h after brushing.

Clinical relevance

Hydrocolloid added to dentifrices as a controlled-release system for F might contribute to a higher anti-caries effect.

Trial registration

NCT02809014

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Acknowledgements

The authors thank all of the participants in this study. The authors also thank Savoy SA for supplying the toothpaste for this study.

Funding

The work was supported by the Higher Education Coordination Improvement Personnel (CAPES)-Brazil through a scholarship to Ms. Alves and by the Savoy Cosmetic Industry SA via the supply of toothpaste.

Author information

Authors and Affiliations

  1. Department of Clinical and Social Dentistry, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil

    Vanessa Feitosa Alves, Vanderlúcia Gomes Moreira, Andréia Felix Soares, Luísa Simões de Albuquerque, Helene Soares Moura & Fábio Correia Sampaio

  2. Lauro Wanderley University Hospital, Federal University of Paraiba, Castelo Branco, s/n., João Pessoa, Paraiba, 58051-900, Brazil

    Alisson de Oliveira Silva

Authors
  1. Vanessa Feitosa Alves
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  2. Vanderlúcia Gomes Moreira
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  3. Andréia Felix Soares
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  4. Luísa Simões de Albuquerque
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  5. Helene Soares Moura
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  6. Alisson de Oliveira Silva
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  7. Fábio Correia Sampaio
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Corresponding author

Correspondence to Vanessa Feitosa Alves.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures in this study were performed in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Alves, V.F., Moreira, V.G., Soares, A.F. et al. A randomized triple-blind crossover trial of a hydrocolloid-containing dentifrice as a controlled-release system for fluoride. Clin Oral Invest 22, 3071–3077 (2018). https://doi.org/10.1007/s00784-018-2395-0

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  • DOI: https://doi.org/10.1007/s00784-018-2395-0

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