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Fragility fractures and delayed wound healing after tooth extraction in Japanese older adults

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Fragility fractures can cause delayed wound healing after tooth extraction, which contributes to an increased risk of osteomyelitis of the jaw. We evaluated whether a history of fragility fracture was associated with increased risk of delayed wound healing after tooth extraction in older adults in Japan.

Materials and methods

Of 5352 people aged 50–89 years in the 2014 basic resident registry of the town of Obuse, the present study included 376 subjects (190 men and 186 women) who completed a structured questionnaire and measurement of the bone mineral densities (BMDs) of the bilateral femoral neck. Delayed wound healing after tooth extraction was self-reported. Fragility fractures were confirmed via examination of hospital medical records. Logistic regression analyses adjusted for age and gender were used to evaluate association of clinical variables with delayed would healing after tooth extractions. Odds ratios (ORs) and the 95% confidence intervals (CIs) of all possible associated variables for the presence of delayed wound healing were calculated.

Results

Subjects with a history of fragility fractures had a significantly higher risk of delayed wound healing compared with those without previous fragility fractures (OR 2.68; 95% CI 1.11–6.46, p = 0.028). This association still remained after adjusted for all other variables (OR 2.70; 95% CI 1.10–6.60, p = 0.030). Delayed wound healing was not significantly associated with the BMD of the femoral neck.

Conclusions

History of fragility fracture may be associated with increased risk of delayed wound healing after tooth extraction in Japanese men and women aged 50–89 years.

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Acknowledgements

We thank Kelly Zammit, BVSc, from Edanz Editing (www.edanzediting.com/ac), for editing a draft of this manuscript. This work was partially funded by JSPS KAKENHI grants provided to AT (Grant numbers JP18K09758 and JP18K09611). This work also received funding from the Japanese Orthopaedic Association and the Japanese Society for Musculoskeletal Medicine to HK, and from the Nakatomi Foundation to SI.

Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University, 1780, Gobara, Hirooka, Shiojiri, Nagano, 399-0781, Japan

    Akira Taguchi

  2. Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Shota Ikegami, Hiroshi Horiuchi, Jun Takahashi & Hiroyuki Kato

  3. Rehabilitation Center, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Shota Ikegami, Ryosuke Tokida & Hiroshi Horiuchi

  4. Center for Osteoporosis and Spinal Disorders, Kamimura Orthopedic Clinic, 595-17, Kotobuki, Matsumoto, 399-0021, Japan

    Mikio Kamimura

  5. Nagano Children’s Hospital, 3100, Toyoshina, Azumino, Nagano, 399-8288, Japan

    Noriko Sakai

Authors
  1. Akira Taguchi
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  2. Shota Ikegami
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  3. Ryosuke Tokida
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  4. Mikio Kamimura
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  5. Noriko Sakai
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  6. Hiroshi Horiuchi
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  7. Jun Takahashi
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  8. Hiroyuki Kato
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Corresponding author

Correspondence to Akira Taguchi.

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Conflict of interest

AT has received consulting fees and lecture fees from Asahi-Kasei Pharma, Daiichi-Sankyo, Teijin Pharma, Astellas Pharma, Taisho Pharma, and Chugai Pharmaceutical. MK received lecture fees from Asahi-Kasei Pharma, Teijin Pharma, Ono Pharmaceutical, Pfizer, and Eli Lilly Japan. SI, RT, NS, HH, JT, and HK declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Taguchi, A., Ikegami, S., Tokida, R. et al. Fragility fractures and delayed wound healing after tooth extraction in Japanese older adults. J Bone Miner Metab 38, 357–362 (2020). https://doi.org/10.1007/s00774-019-01063-3

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  • DOI: https://doi.org/10.1007/s00774-019-01063-3

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