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Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

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Abstract

The potential link between infection with Chlamydia pneumoniae or Helicobacter pylori and osteoporosis has not been investigated in population-based longitudinal studies. A total of 250 healthy postmenopausal women who participated in a prospective cohort study were evaluated for IgG antibodies directed against C. pneumoniae and H. p ylori, osteoprotegerin (OPG), the receptor activator of nuclear factor kappa B ligand (RANKL), CrossLaps, and osteocalcin. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine at baseline and at follow-up 5.8 years later. There were no significant differences in age-adjusted bone turnover markers, OPG, RANKL, the RANKL/OPG ratio, and BMD between the C. p neumoniae and H. p ylori IgG seropositive and seronegative subjects (P > 0.05). Neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with age-and body mass index-adjusted BMD at the femoral neck and lumbar spine or bone loss at the 5.8-year follow-up. In logistic regression analysis, neither C. p neumoniae nor H. p ylori IgG seropositivities predicted incident lumbar or spine osteoporosis 5.8 years later. In conclusion, neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with bone turnover markers, the RANKL/OPG ratio, BMD, or bone loss in postmenopausal women. In addition, chronic infection with C. p neumoniae or H. p ylori did not predict incident osteoporosis among this group of women.

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References

  1. Watson C, Alp NJ (2008) Role of Chlamydia pneumoniae in atherosclerosis. Clin Sci (Lond) 114:509–531

    Article  CAS  Google Scholar 

  2. Campbell LA, Kuo CC (2002) Chlamydia pneumoniae pathogenesis. J Med Microbiol 51:623–625

    Article  PubMed  Google Scholar 

  3. Bailey L, Engstrom P, Nordstrom A, Bergstrom S, Waldenstrom A, Nordstrom P (2008) Chlamydia pneumoniae infection results in generalized bone loss in mice. Microbes Infect 10:1175–1181

    Article  CAS  PubMed  Google Scholar 

  4. Rizzo A, Di Domenico M, Carratelli CR, Mazzola N, Paolillo R (2011) Induction of proinflammatory cytokines in human osteoblastic cells by Chlamydia pneumoniae. Cytokine 56:450–457

    Article  CAS  PubMed  Google Scholar 

  5. Di Pietro M, Schiavoni G, Sessa V, Pallotta F, Costanzo G, Sessa R (2013) Chlamydia pneumoniae and osteoporosis-associated bone loss: a new risk factor? Osteoporos Int 24:1677–1682

    Article  CAS  PubMed  Google Scholar 

  6. Gasbarrini A, Franceschi F, Armuzzi A, Ojetti V, Candelli M, Torre ES, De Lorenzo A, Anti M, Pretolani S, Gasbarrini G (1999) Extradigestive manifestations of Helicobacter pylori gastric infection. Gut 45(Suppl 1):I9–I12

    Article  PubMed  PubMed Central  Google Scholar 

  7. Papamichael KX, Papaioannou G, Karga H, Roussos A, Mantzaris GJ (2009) Helicobacter pylori infection and endocrine disorders: is there a link? World J Gastroenterol 15:2701–2707

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ozdem S, Akcam M, Yilmaz A, Gultekin M, Artan R (2007) Biochemical markers of bone metabolism in children with Helicobacter pylori infection. Dig Dis Sci 52:967–972

    Article  CAS  PubMed  Google Scholar 

  9. Figura N, Gennari L, Merlotti D, Lenzi C, Campagna S, Franci B, Lucani B, Trabalzini L, Bianciardi L, Gonnelli C, Santucci A, Nut A (2005) Prevalence of Helicobacter pylori infection in male patients with osteoporosis and controls. Dig Dis Sci 50:847–852

    Article  CAS  PubMed  Google Scholar 

  10. Kakehasi AM, Rodrigues CB, Carvalho AV, Barbosa AJ (2009) Chronic gastritis and bone mineral density in women. Dig Dis Sci 54:819–824

    Article  PubMed  Google Scholar 

  11. Kakehasi AM, Mendes CM, Coelho LG, Castro LP, Barbosa AJ (2007) The presence of Helicobacter pylori in postmenopausal women is not a factor to the decrease of bone mineral density. Arq Gastroenterol 44:266–270

    Article  PubMed  Google Scholar 

  12. Tohidi M, Akbarzadeh S, Larijani B, Kalantarhormozi M, Ostovar A, Assadi M, Vahdat K, Farrokhnia M, Sanjdideh Z, Amirinejad R, Nabipour I (2012) Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women. Bone 51:876–881

    Article  CAS  PubMed  Google Scholar 

  13. World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 843:1–129

  14. Maass M, Gieffers J, Krause E, Engel PM, Bartels C, Solbach W (1998) Poor correlation between microimmunofluorescence serology and polymerase chain reaction for detection of vascular Chlamydia pneumoniae infection in coronary artery disease patients. Med Microbiol Immunol 187:103–106

    Article  CAS  PubMed  Google Scholar 

  15. Danesh J, Whincup P, Lewington S, Walker M, Lennon L, Thomson A, Wong YK, Zhou X, Ward M (2002) Chlamydia pneumoniae IgA titres and coronary heart disease; prospective study and meta-analysis. Eur Heart J 23:371–375

    Article  CAS  PubMed  Google Scholar 

  16. Al-Sammak F, Kalinski T, Weinert S, Link A, Wex T, Malfertheiner P (2013) Gastric epithelial expression of IL-12 cytokine family in Helicobacter pylori infection in human: is it head or tail of the coin? PLoS One 8:e75192

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Romero-Adrian TB, Leal-Montiel J, Monsalve-Castillo F, Mengual-Moreno E, McGregor EG, Perini L, Antunez A (2010) Helicobacter pylori: bacterial factors and the role of cytokines in the immune response. Curr Microbiol 60:143–155

    Article  CAS  PubMed  Google Scholar 

  18. Hofbauer LC, Kuhne CA, Viereck V (2004) The OPG/RANKL/RANK system in metabolic bone diseases. J Musculoskelet Neuronal Interact 4:268–275

    CAS  PubMed  Google Scholar 

  19. Nabipour I, Larijani B, Vahdat K, Assadi M, Jafari SM, Ahmadi E, Movahed A, Moradhaseli F, Sanjdideh Z, Obeidi N, Amiri Z (2009) Relationships among serum receptor of nuclear factor-kappaB ligand, osteoprotegerin, high-sensitivity C-reactive protein, and bone mineral density in postmenopausal women: osteoimmunity versus osteoinflammatory. Menopause 16:950–955

    Article  PubMed  Google Scholar 

  20. Davidson M, Kuo CC, Middaugh JP, Campbell LA, Wang SP, Newman WP 3rd, Finley JC, Grayston JT (1998) Confirmed previous infection with Chlamydia pneumoniae (TWAR) and its presence in early coronary atherosclerosis. Circulation 98:628–633

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This project was supported jointly by a grant from Bushehr University of Medical Sciences and Health Services; the Ministry of Health; Tehran Endocrine Research Center; Tehran University of Medical Science, Tehran, Islamic Republic of Iran; and Bushehr Province Research Committee (PGHRC: 1385.234.345). The authors thank Dr. Syed Reza Imami, Shiva Mosadeghzadeh, and Zahra Amiri for assistance in the field work.

Conflict of interest

An award was given to Iraj Nabipour by “Novo Nordisk Pars” (The Best Innovator of Diabetes in Iran 2013). All other authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

    Mohammad Reza Kalantarhormozi & Katayoun Raissi

  2. The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

    Majid Assadi

  3. Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

    Katayoun Vahdat, Afshin Ostovar, Hossein Darabi, Shokrollah Farrokhi & Sina Dobaradaran

  4. Division of Endocrinology and Metabolism, University of Kansas Medical Center, Kansas City, KS, USA

    Kamyar Asadipooya

  5. Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran

    Maryam Farrokhnia & Iraj Nabipour

  6. The Persian Gulf Tropical Medicine Research Center, Boostan 19 Alley, Imam Khomeini St, 7514763448, Bushehr, Iran

    Iraj Nabipour

Authors
  1. Mohammad Reza Kalantarhormozi
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  2. Majid Assadi
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  3. Katayoun Vahdat
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  4. Kamyar Asadipooya
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  5. Afshin Ostovar
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  6. Katayoun Raissi
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  7. Hossein Darabi
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  8. Shokrollah Farrokhi
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  9. Sina Dobaradaran
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  10. Maryam Farrokhnia
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  11. Iraj Nabipour
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Corresponding author

Correspondence to Iraj Nabipour.

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Kalantarhormozi, M.R., Assadi, M., Vahdat, K. et al. Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study. J Bone Miner Metab 34, 422–428 (2016). https://doi.org/10.1007/s00774-015-0688-9

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  • DOI: https://doi.org/10.1007/s00774-015-0688-9

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