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Therapie von Hirnmetastasen und Meningeosis neoplastica

Therapy of brain metastases and neoplastic meningitis

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Zusammenfassung

Die Weiterentwicklung der systemischen Chemotherapie maligner Tumoren mit Einführung neuer Substanzen in die Therapie hat bisher noch nicht zu einer Änderung im Therapiekonzept bei zerebraler Metastasierung geführt. Die Schwierigkeit in der Bewertung des Stellenwerts dieser neuen Medikamente liegt im Fehlen von Daten randomisierter Studien zur Untersuchung des Nutzens zielgerichteter Substanzen allein oder in Kombination mit anderen Therapiemodalitäten. Der vorliegende Artikel möchte aktuelle Daten zur Therapie von Hirnmetastasen solider Tumoren zusammenfassen und eine Einordnung in die bestehenden Therapieempfehlungen vornehmen. Es sollen insbesondere die Bedeutung multimodaler Konzepte und der Stellenwert zielgerichteter Substanzen aufgezeigt werden, da hier potenziell eine Weiterentwicklung aktueller Therapieempfehlungen zu erwarten ist.

Abstract

The continuous development of systemic chemotherapy of malignant tumors and the introduction of novel substances into the therapeutic regimen has not so far changed the therapeutic concept for cerebral metastases. Difficulties confounding the evaluation of these new substances are due to the fact that there are virtually no randomized studies which demonstrate the benefit of targeted therapies alone or in combination with other therapeutic modalities. The intention of this article is to review current data on the therapy of solid tumor brain metastases and to put them into relation to current therapeutic recommendations. Special emphasis is placed on the importance of multimodal concepts and the value of targeted therapies, as further development of therapeutic recommendations are to be expected in this field.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehungen hin:

L.-O. Mügge erhält Referentenhonorare von Novartis, Roche, Janssen-Cilag, Celgene.

A. Schüler erklärt, dass kein Interessenkonflikt besteht.

A. Hochhaus: Forschungsuntersützung und Honorare von Novartis, BMS und Ariad.

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  1. Klinik für Innere Medizin II, Abt. Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Erlanger Allee 101, 07740, Jena, Deutschland

    L.-O. Mügge & A. Hochhaus

  2. Klinik für Strahlentherapie, Universitätsklinikum Jena, Jena, Deutschland

    A. Schüler

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Mügge, LO., Schüler, A. & Hochhaus, A. Therapie von Hirnmetastasen und Meningeosis neoplastica. Onkologe 17, 292–307 (2011). https://doi.org/10.1007/s00761-010-1961-0

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