Abstract
Both sulfonopeptides and phosphonopeptides are important analogs of naturally occurring peptides and have been widely used as enzyme inhibitors and haptens for producing catalytic antibodies due to their tetrahedrally structural features. A series of hybrid sulfonophosphinodipeptides composing of taurines and 1-aminoalkylphosphinic acids were first and conveniently synthesized in satisfactory to good yields via a Mannich-type reaction of N-benzyloxycarbonylaminoalkanesulfonamides, aldehydes, and aryldichlorophosphines, and subsequent hydrolysis. The current method provides an efficient and direct synthesis of hybrid sulfonophosphinodipeptides.
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Acknowledgments
The project was supported by National Natural Science Foundation of China (No. 20092013 and 20772005), Beijing Natural Science Foundation (No. 2092022), and University Innovative Research Grant award (10Si003), BUCT, 2010.
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Meng, F., He, F., Song, X. et al. Facile synthesis of hybrid sulfonophosphinodipeptides composing of taurines and 1-aminoalkylphosphinic acids. Amino Acids 43, 423–429 (2012). https://doi.org/10.1007/s00726-011-1098-5
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DOI: https://doi.org/10.1007/s00726-011-1098-5