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Direct synthesis of phosphinopeptides containing C-terminal α-aminoalkylphosphinic acids

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Abstract

A series of phosphinopeptides containing C-terminal α-aminoalkylphosphinic acids were prepared in good yields directly in one-pot reactions of 2-(N-benzoxycarbonylamino)alkanamides/peptide amides, aldehydes, and aryldichlorophosphines, followed by hydrolysis. In the current method, the peptide bond was formed in a Mannich-type reaction.

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Acknowledgments

The project was supported partly by National Natural Science Foundation of China (No. 20092013 and 20772005).

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Authors and Affiliations

  1. State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, 100029, Beijing, People’s Republic of China

    Fanhua Meng & Jiaxi Xu

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  1. Fanhua Meng
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  2. Jiaxi Xu
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Correspondence to Jiaxi Xu.

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Meng, F., Xu, J. Direct synthesis of phosphinopeptides containing C-terminal α-aminoalkylphosphinic acids. Amino Acids 39, 533–538 (2010). https://doi.org/10.1007/s00726-009-0469-7

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