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Asymmetric synthesis of all stereoisomers of 6-methylpipecolic acids

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Summary.

 Asymmetric synthesis of all four stereoisomers of 6-methylpipecolic acids with high enantiomeric purity via iterative AD reaction, starting from 1,6-heptadiene, has been described.

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Authors and Affiliations

  1.  Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai, Japan, , , , , , JP

    H. Takahata

  2.  Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Toyama, Japan, , , , , , JP

    M. Shimizu

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  1. H. Takahata
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  2. M. Shimizu
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Additional information

Received March 25, 2002 Accepted June 15, 2002 Published online January 30, 2003

Authors' address: Hiroki Takahata, Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981-8558, Japan, E-mail: takahata@tohoku-pharm.ac.jp

RID="*"

ID="*"  The stereo-configurations of 8 and 9 in Fig. 3 and 12 in Fig. 4 show only major isomers.

RID="**"

ID="**"  The absolute configurations of 11 and 14

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Takahata, H., Shimizu, M. Asymmetric synthesis of all stereoisomers of 6-methylpipecolic acids. Amino Acids 24, 267–272 (2003). https://doi.org/10.1007/s00726-002-0411-8

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  • DOI: https://doi.org/10.1007/s00726-002-0411-8

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