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The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile

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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary.

 This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.

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Authors and Affiliations

  1. Department of Chemistry, The University of Western Australia, Crawley WA, 6009 Australia, , , , , , AU

    Robert V. Stick & Andrew G. Watts

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  1. Robert V. Stick
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  2. Andrew G. Watts
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Received October 16, 2001. Accepted November 7, 2001

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Stick, R., Watts, A. The Chameleon of Retaining Glycoside Hydrolases and Retaining Glycosyl Transferases: The Catalytic Nucleophile. Monatshefte fuer Chemie 133, 541–554 (2002). https://doi.org/10.1007/s007060200027

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  • DOI: https://doi.org/10.1007/s007060200027

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