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Design and synthesis of novel totarol derivatives bearing carbamate moiety as potential fungicides

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Abstract

A series of totarol derivatives were synthesized by introducing the carbamate moiety into the molecular structure, and their antifungal effects against Pyricularia grisea, Fusarium graminearum, Botrytis cinerea, Fusarium oxysporum f.sp.lycopeerisci, and Fusarium oxysporum f.sp.vasinfectum were evaluated. The antifungal results showed that most of target compounds have good antifungal activities against the tested fungi. Noteworthily, the EC50 value of compound substituted with 2-CH3-Ph against Botrytis cinerea was 26.6 μg/cm3. Tosyl-substituted derivative demonstrated to possess antifungal activities against Pyricularia grisea, Fusarium graminearum, and Botrytis cinerea with EC50 value of 35.8, 20.9 and 23.8 μg/cm3, respectively.

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Acknowledgements

The authors gratefully acknowledge the High Level Introduction of Talent Research Start-up Foundation of Yangzhou University (No. 137012166).

Funding

The High Level Introduction of Talent Research Start-up Foundation of Yangzhou University, 137012166, Fei Meng.

Author information

Author notes

  1. Yuexiao Lu and Yangyang Cui contributed equally to this work.

Authors and Affiliations

  1. Institute of Pesticide, College of Plant Protection, Yangzhou University, Yangzhou, 225009, China

    Yuexiao Lu, Yangyang Cui, Wenchao Yang & Fei Meng

  2. National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass, Nanjing Forestry University, Nanjing, 210037, China

    Wenchao Yang

Authors
  1. Yuexiao Lu
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  2. Yangyang Cui
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  3. Wenchao Yang
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  4. Fei Meng
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Correspondence to Fei Meng.

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Lu, Y., Cui, Y., Yang, W. et al. Design and synthesis of novel totarol derivatives bearing carbamate moiety as potential fungicides. Monatsh Chem 154, 915–923 (2023). https://doi.org/10.1007/s00706-023-03102-2

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  • DOI: https://doi.org/10.1007/s00706-023-03102-2

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