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Fabrication of a photo- and pH-sensitive micelle by self-assembly of azobenzene polyglycerol for anticancer drug delivery

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Abstract

Smart materials can respond to external physical or chemical stimuli in controlled conditions. Azo dyes are widely used in industry and medicine due to their physicochemical properties. The photoisomerization ability of azo compounds has made them attractive candidates for the design of compounds with photo-responsive properties and use in drug delivery. In this work, a light-sensitive polymer containing azobenzene as the core and hyperbranched polyglycerol as the shell (called Azo-HPG) was synthesized via anionic ring-opening polymerization. The structure of Azo-HPG was analyzed by FT-IR, NMR, DLS, and GPC. The ability of polymer in the delivery of doxorubicin was investigated under UV irradiation and different pH conditions.

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The datasets generated and analyzed during the current study are included in this published article.

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Acknowledgements

The authors gratefully acknowledge Prof. Dr. Mohsen Adeli from the Lorestan University (Iran) for all his helps, valuable advices and assistance in the experiments and discussions, as well as Dr. Ehsan Mohammadifar from the Institute of Chemistry and Biochemistry, Freie Universität Berlin (Germany) for GPC measurements.

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Authors and Affiliations

  1. Department of Chemistry, Malayer University, Malayer, Iran

    Zeinab Rafiee

  2. Department of Chemistry, Tuyserkan Branch, Islamic Azad University, Tuyserkan, Iran

    Ali Bodaghi

  3. Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran

    Sakineh Omidi

Authors
  1. Zeinab Rafiee
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  2. Ali Bodaghi
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  3. Sakineh Omidi
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Correspondence to Zeinab Rafiee.

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Rafiee, Z., Bodaghi, A. & Omidi, S. Fabrication of a photo- and pH-sensitive micelle by self-assembly of azobenzene polyglycerol for anticancer drug delivery. Monatsh Chem 154, 259–265 (2023). https://doi.org/10.1007/s00706-023-03036-9

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  • DOI: https://doi.org/10.1007/s00706-023-03036-9

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