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An efficient approach for the synthesis of novel series of 1,3-dihydrospiro[indene-2,6ʹ-[1,3]thiazine] derivatives

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Abstract

Facile synthesis of trimethoxyphenyl-1,3-dihydrospiro[indene-2,6ʹ-[1,3]thiazines was achieved during reaction of trimethoxyphenyl hydrazinecarbonothioyl hydrazinecarbothioamides with 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)propanedinitrile in dry THF as a solvent. The products were obtained in good to very good yields (78–90%). The structure assignment of all obtained products has been confirmed by 1H and 13C NMR, IR, and mass spectra in addition to elemental analyses. The possible mechanism described the products formation was also discussed.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt

    Sara M. Mostafa, Ashraf A. Aly & Asmaa H. Mohamed

  2. Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany

    Stefan Bräse

  3. Institute of Biological and Chemical Systems (IBCS-FMS), Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany

    Stefan Bräse

Authors
  1. Sara M. Mostafa
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  2. Ashraf A. Aly
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  3. Stefan Bräse
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  4. Asmaa H. Mohamed
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Correspondence to Ashraf A. Aly.

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Mostafa, S.M., Aly, A.A., Bräse, S. et al. An efficient approach for the synthesis of novel series of 1,3-dihydrospiro[indene-2,6ʹ-[1,3]thiazine] derivatives. Monatsh Chem 153, 87–94 (2022). https://doi.org/10.1007/s00706-021-02878-5

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  • DOI: https://doi.org/10.1007/s00706-021-02878-5

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