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Synthesis, crystal structure, redox property, and cytotoxic activity of a dinuclear cobalt(II) complex bearing a tetradentate benzimidazole ligand

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Abstract

A tetradentate benzimidazole ligand cis,cis,cis,cis-2,2′,2″,2‴-(cyclopentane-1,2,3,4-tetrayl)tetrakis(1H-benzo[d]imidazole) (cttb) and its dinuclear cobalt(II) complex [Co2(cttb)Cl4]·2DMF·H2O have been synthesized and characterized by X-ray single-crystal structure analysis. In the complex, each central Co2+ is chelated by two nitrogen atoms of the ligand and bound to two chloride ions, forming a distorted tetrahedron arrangement. The complex showed a quasi-reversible redox property for the Co(III)/Co(II) couple and exhibited inhibition on the growth of Eca109 cancer cell with the IC50 value of 37.28 μM, which is lower than that of cisplatin.

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Acknowledgements

This work was financially supported by the Natural Science Foundation of Guangdong Province, China (No. 2017A030307036), Special funds for public welfare research and capacity building in Guangdong Province (No. 2015A020211038 and 2016A010103042), Research Group of Rare earth resource exploiting and luminescent materials (No. 2017KCXTD022).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institutes, Lingnan Normal University, Zhanjiang, China

    Rong-Kai Pan, Jiang-Li Song, Guo-Bi Li, Chao-Yan Lu & Sheng-Gui Liu

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  1. Rong-Kai Pan
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  2. Jiang-Li Song
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  3. Guo-Bi Li
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Correspondence to Sheng-Gui Liu.

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Pan, RK., Song, JL., Li, GB. et al. Synthesis, crystal structure, redox property, and cytotoxic activity of a dinuclear cobalt(II) complex bearing a tetradentate benzimidazole ligand. Monatsh Chem 150, 1453–1459 (2019). https://doi.org/10.1007/s00706-019-02477-5

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  • DOI: https://doi.org/10.1007/s00706-019-02477-5

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