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Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication

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Abstract

We present a case of the acute intoxication of a 17-year-old patient after ingestion of 6 g of quetiapine in combination with 1 g of lamotrigine. Due to the severe tachycardia, hypertension, and prolonged QTc without improvement after standard treatment, the patient was treated with Intralipid 20% intravenous infusion recommended by the Toxicologic Information Centre. After lipid infusion, the QTc rapidly normalised and tachycardia resolved to sinus rhythm. The patient was transferred to psychiatry intensive care on the third day after admission.

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Acknowledgements

The article was written with the support of Specific University Research provided by MŠMT (MUNI/A/1111/2018), supported by MH CZ—DRO (FNBr, 65269705), and Progres Q25/LF1 and Q29/LF1.

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Authors and Affiliations

  1. Department of Paediatric Anaesthesiology and Intensive Care Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic

    Jozef Klučka, Martina Kosinová, Štourač Petr, Milan Kratochvíl & Yvona Sedláčková

  2. Department of Paediatric, University Hospital Brno, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic

    Tomáš Juřenčák & Petr Jabandžiev

  3. J. Heyrovsky Institute of Physical Chemistry of the Academy of Sciences of the Czech Republic, Dolejškova 3, 182 23, Prague 8, Czech Republic

    Navrátil Tomáš

  4. Toxicological Information Centre, Department of Occupational Medicine, First Faculty of Medicine, Charles University and General University Hospital Prague, Na Bojišti 1, 120 00, Prague, Czech Republic

    Daniela Pelclová

Authors
  1. Jozef Klučka
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  2. Tomáš Juřenčák
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  3. Martina Kosinová
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  4. Štourač Petr
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  5. Milan Kratochvíl
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  6. Yvona Sedláčková
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  7. Navrátil Tomáš
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  8. Daniela Pelclová
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  9. Petr Jabandžiev
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Correspondence to Štourač Petr.

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Klučka, J., Juřenčák, T., Kosinová, M. et al. Intralipid infusion in paediatric patient with quetiapine and lamotrigine intoxication. Monatsh Chem 150, 1711–1714 (2019). https://doi.org/10.1007/s00706-019-02423-5

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  • DOI: https://doi.org/10.1007/s00706-019-02423-5

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