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An efficient catalyst-free approach for the synthesis of novel isoxazolo[5,4-b]pyridine derivatives via one-pot three-component reaction

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Abstract

A catalyst-free, one-pot, three-component condensation procedure for the synthesis of novel isoxazolo[5,4-b]pyridine derivatives has been reported by condensation of isatins, 3-methylisoxazol-5-amine, and cyclic enolizable carbonyl compounds in ethylene glycol at 80 °C. The structures of the synthesized compounds have been confirmed by spectral and X-ray studies. Crystal packing of one compound has also been reported. Less reaction time, easy work-up, and high yields are the important features of the present protocol.

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Acknowledgements

K. M. thanks Dyal Singh College, DU, for the grant of Teacher Fellowship and S. K. thanks CSIR, New Delhi, India for JRF and SRF. Authors acknowledge University of Delhi for providing Research Grant and DST purse grant.

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Authors and Affiliations

  1. Department of Chemistry, University of Delhi, Delhi, 110007, India

    Kalawati Meena, Sudesh Kumari & Jitender M. Khurana

  2. Dyal Singh College, University of Delhi, Lodhi Road, Delhi, 110003, India

    Kalawati Meena & Amita Malik

Authors
  1. Kalawati Meena
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  2. Sudesh Kumari
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  3. Jitender M. Khurana
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  4. Amita Malik
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Corresponding author

Correspondence to Jitender M. Khurana.

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Meena, K., Kumari, S., Khurana, J.M. et al. An efficient catalyst-free approach for the synthesis of novel isoxazolo[5,4-b]pyridine derivatives via one-pot three-component reaction. Monatsh Chem 149, 1841–1848 (2018). https://doi.org/10.1007/s00706-018-2205-z

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  • DOI: https://doi.org/10.1007/s00706-018-2205-z

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