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Historical injection solutions of quinine analyzed by HPLC/MS

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Abstract

Two injection solutions of quinine 79, 77 resp., years were analyzed using RP-HPLC. The conditions of separation were optimized. The quinine content is decreased about 13% for 79-year-old sample and about 8% for 77-year-old sample, respectively. Quinotoxine has been found as the decomposition product. The compounds were identified by MS2, and the ESI fragmentation mechanisms of compounds found were proposed.

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Acknowledgements

The authors are grateful for the financial support by the Grant projects SVV and Progress Q46 of Charles University.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

    Karel Kudláček, Karel Nesměrák & Petr Kozlík

  2. Department of Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

    Martin Štícha

  3. Czech Pharmaceutical Museum, Faculty of Pharmacy in Hradec Králové, Charles University, Kuks, Czech Republic

    Jan Babica

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  1. Karel Kudláček
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  2. Karel Nesměrák
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  3. Martin Štícha
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  4. Petr Kozlík
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  5. Jan Babica
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Correspondence to Karel Nesměrák.

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Kudláček, K., Nesměrák, K., Štícha, M. et al. Historical injection solutions of quinine analyzed by HPLC/MS. Monatsh Chem 148, 1613–1618 (2017). https://doi.org/10.1007/s00706-017-1940-x

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  • DOI: https://doi.org/10.1007/s00706-017-1940-x

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