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Synthesis of some new quinazolin-4(3H)-one derivatives and evaluation of their anticonvulsant activity

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Abstract

We reported the synthesis of a novel series of quinazolin-4(3H)-one derivatives bearing oxadiazole, thiadiazole, and other moieties in the 3-position of the quinazolinone nucleus using appropriate synthetic route. The compounds were evaluated for their anticonvulsant activity using picrotoxin model, GABA-A receptor antagonist. Five compounds showed significantly prolonged times for convulsions compared with the standard drug phenobarbital.

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Acknowledgments

We are grateful to Professor Gerhard Maas from Institute of Organic Chemistry I, University of Ulm, Germany for assistance with NMR measurements.

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Authors and Affiliations

  1. Preparatory Year Deanship, Basic Science Department, Prince Sattam Bin Abdulaziz University, 151 Alkharj, 11942, Kingdom of Saudi Arabia

    Farag A. El-Essawy

  2. Chemistry Department, Faculty of Science, Menoufia University, Shibin Al Kawm, Egypt

    Nader M. Boshta, Farag A. El-Essawy, Abd El-Hamid Ismail & Nancy E. Wahba

  3. Faculty of Pharmacy, Sinai University, Al-Arish, Egypt

    Ramy M. Ammar

Authors
  1. Nader M. Boshta
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  2. Farag A. El-Essawy
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  3. Ramy M. Ammar
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  4. Abd El-Hamid Ismail
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  5. Nancy E. Wahba
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Corresponding author

Correspondence to Nader M. Boshta.

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Boshta, N.M., El-Essawy, F.A., Ammar, R.M. et al. Synthesis of some new quinazolin-4(3H)-one derivatives and evaluation of their anticonvulsant activity. Monatsh Chem 147, 2031–2042 (2016). https://doi.org/10.1007/s00706-016-1710-1

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  • DOI: https://doi.org/10.1007/s00706-016-1710-1

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