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Antimicrobial activity of mannose-derived glycosides

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Abstract

A set of 14 synthetic mannolipid-mimicking O-mannosides, S-mannosides, and mannosylsulfones varying in aglycone length were evaluated for their antimicrobial activity towards yeast Candida albicans as well as Gram-positive and Gram-negative bacteria, Staphylococcus aureus and Escherichia coli, respectively. S. aureus was the most susceptible to dodecyl α-d-mannopyranoside showing MIC value of 78 μM, while dodecyl α-d-thiomannopyranoside was superior yeast inhibitor exhibiting twofold lower MIC value. On the other hand, E. coli was resistant to both dodecyl glycosides. Mannosides exposure on RAW 264.7 cell line murine macrophages revealed the tight structure—immunobiological activity pattern. No significant cytotoxic effect and suppression of proliferation as a consequence of cell injury following 24 h exposure with 1–100 μg/cm3 mannosides were observed.

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Acknowledgments

This work was supported by the Slovak Research and Development Agency (the project APVV-0484-12), Scientific Grant Agency of the Ministry of Education of Slovak Republic and Slovak Academy of Sciences (the project VEGA-2/0064/15), and the Slovak State Programme Project No. 2003SP200280203. Dr. Vladimír Puchart is appreciated for helpful discussion.

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Authors and Affiliations

  1. Department of Cellular and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, 832 32, Bratislava, Slovakia

    Andrea Bilková

  2. Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravska cesta 9, 845 38, Bratislava, Slovakia

    Ema Paulovičová, Lucia Paulovičová & Monika Poláková

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  1. Andrea Bilková
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  2. Ema Paulovičová
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  3. Lucia Paulovičová
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  4. Monika Poláková
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Correspondence to Monika Poláková.

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Bilková, A., Paulovičová, E., Paulovičová, L. et al. Antimicrobial activity of mannose-derived glycosides. Monatsh Chem 146, 1707–1714 (2015). https://doi.org/10.1007/s00706-015-1530-8

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  • DOI: https://doi.org/10.1007/s00706-015-1530-8

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