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A simple, rapid, and efficient N-Boc protection of amines under ultrasound irradiation and catalyst-free conditions

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Abstract

A green and simple approach for the N-Boc protection on structurally diverse amines under ultrasound irradiation is described. Selective N-Boc protection was achieved in excellent isolated yield in a short reaction time at room temperature. Mild conditions, inexpensive and an easily available reagent, and absence of any auxiliary substances are the main advantages of this procedure.

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Acknowledgments

This work was generously supported by the Direction Génerale de la Recherche Scientifique et du Développement Technologique, DGRS-DT, Algerian Ministry of Scientific Research (FNR), and fruitful discussions with Dr. Malika Ibrahim-Ouali, Université d’Aix Marseille II France, and Dr. Zinelaabidine Cheraiet. The authors are thankful to students of Master II: Rachida Mansouri and Louar Radia for their help in this work.

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Authors and Affiliations

  1. LCOA, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department, Badji Mokhtar-Annaba University, Box 12, 23000, Annaba, Algeria

    Aïcha Amira, Hacène K’tir, Malika Berredjem & Nour-Eddine Aouf

Authors
  1. Aïcha Amira
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  2. Hacène K’tir
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  3. Malika Berredjem
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  4. Nour-Eddine Aouf
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Corresponding author

Correspondence to Nour-Eddine Aouf.

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Amira, A., K’tir, H., Berredjem, M. et al. A simple, rapid, and efficient N-Boc protection of amines under ultrasound irradiation and catalyst-free conditions. Monatsh Chem 145, 509–515 (2014). https://doi.org/10.1007/s00706-013-1094-4

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  • DOI: https://doi.org/10.1007/s00706-013-1094-4

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