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An environmentally benign procedure for the synthesis of substituted 2-thiobenzothiazoles, 2-thiobenzoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols

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Abstract

An improved environmentally benign procedure for the synthesis of substituted 2-thio-benzothia(oxa)zoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols by cyclization of 2-aminophenols, 2-aminothiophenols, 1,2-phenylenediamines, or 2-amino-3-hydroxypyridines with potassium O-ethyldithiocarbonate in PEG 400 or glycerol under directed microwave irradiation is described. The method can be applied to the synthesis of a variety of derivatives.

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Acknowledgments

The authors acknowledge financial support (in part) from the Spanish Ministerio de Ciencia e Innovación (project CTQ2008-04313/BQU) and from the Bulgarian National Science Fund (grant DO1-873).

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Authors and Affiliations

  1. Faculty of Chemistry, University of Sofia, 1 James Bourchier Avenue, 1164, Sofia, Bulgaria

    Todor G. Deligeorgiev, Stefka S. Kaloyanova & Nedyalko Y. Lesev

  2. Facultad de Farmacia, Universidad de Alcala, 28871, Alcala de Henares, Madrid, Spain

    Juan J. Vaquero

Authors
  1. Todor G. Deligeorgiev
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  2. Stefka S. Kaloyanova
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  3. Nedyalko Y. Lesev
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  4. Juan J. Vaquero
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Corresponding author

Correspondence to Todor G. Deligeorgiev.

Additional information

Dedicated to Professor Julio Álvarez-Builla on the occasion of his 65th birthday.

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Deligeorgiev, T.G., Kaloyanova, S.S., Lesev, N.Y. et al. An environmentally benign procedure for the synthesis of substituted 2-thiobenzothiazoles, 2-thiobenzoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols. Monatsh Chem 142, 895–899 (2011). https://doi.org/10.1007/s00706-011-0551-1

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  • DOI: https://doi.org/10.1007/s00706-011-0551-1

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