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A facile approach to substituted acrylates by regioselective and stereoselective addition of thiols and amines to an alkynyl ester in water

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Abstract

Water-promoted hydrothiolation and hydroamination of ethyl propiolate leading to highly regioselective and stereoselective formation of thioacrylates and β-enamino esters in excellent yields, by a simple, efficient, and environmentally friendly reaction procedure without employing any hazardous reagent or solvent is reported.

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Acknowledgments

We acknowledge the financial support received from the National Institute of Pharmaceutical Education and Research.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, Mohali, Punjab, 160062, India

    Nitin A. Randive, Varun Kumar & Vipin A. Nair

Authors
  1. Nitin A. Randive
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  2. Varun Kumar
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  3. Vipin A. Nair
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Correspondence to Vipin A. Nair.

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Randive, N.A., Kumar, V. & Nair, V.A. A facile approach to substituted acrylates by regioselective and stereoselective addition of thiols and amines to an alkynyl ester in water. Monatsh Chem 141, 1329–1332 (2010). https://doi.org/10.1007/s00706-010-0399-9

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  • DOI: https://doi.org/10.1007/s00706-010-0399-9

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