Summary.
Environment-friendly three component condensation reactions of cyclic 1,3-diketones, 4-nitrobenzaldehyde, and alkyl or aryl isocyanides to afford the corresponding tetrahydrobenzofuran derivatives in water in high yields within one hour are reported.
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Shaabani, A., Teimouri, M. & Bijanzadeh, H. A Novel Three-Component Tetrahydrobenzofuran Synthesis. Monatshefte für Chemie 135, 441–446 (2004). https://doi.org/10.1007/s00706-003-0070-9
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DOI: https://doi.org/10.1007/s00706-003-0070-9