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Genomic structural variation in affective, anxiety, and stress-related disorders

  • Psychiatry and Preclinical Psychiatric Studies - Review Article
  • Published:
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Abstract

Anxiety and stress-related disorders are common and debilitating mental diseases. Genetic factors as well as environmental factors and life events contribute to their pathogenesis and partly mediate treatment response. However, these disorders are clinically heterogeneous, genetically complex, and the exact genetic causes are still unclear. Recently, some evidence has emerged for structural variation including copy number variants and small deletions/duplications to be associated with mental disorders. Here, the current state of knowledge on the role of genomic structural variation in affective, anxiety and stress-related disorders is reviewed, followed by a critical discussion of present methods to detect structural changes, future directions, and clinical implications including a potential role in personalized medicine.

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Acknowledgments

This work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG), SFB-TRR-58, projects C02 (KD, JD), Z02 (JD) and SENSHIN Medical Research Foundation (SO). We are grateful to H. Mishima and Y. Yoshioka for their support.

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Authors and Affiliations

  1. Center of Mental Health, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Würzburg, Würzburg, Germany

    Shinji Ono, Katharina Domschke & Jürgen Deckert

  2. Department of Psychiatry, Nagasaki University Graduate School of Medicine, Nagasaki, Japan

    Shinji Ono

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  1. Shinji Ono
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  2. Katharina Domschke
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  3. Jürgen Deckert
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Correspondence to Shinji Ono.

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Ono, S., Domschke, K. & Deckert, J. Genomic structural variation in affective, anxiety, and stress-related disorders. J Neural Transm 122, 69–78 (2015). https://doi.org/10.1007/s00702-014-1309-9

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