Abstract
The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age ≤45 years) Parkinson’s disease was identified and compared with late-onset patients (age >50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.
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References
Berg D, Schweitzer K, Leitner P et al (2005) Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson’s disease. Brain 128:3000–3011
Cao L, Zhang T, Xiao Q et al (2007) The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson’s disease. Mov Disord 22:2439–2442
Chan DKY, Cordato D, Triet Bui, Mellick G (2004) Comparison of environmental and genetic factors for Parkinson’s disease between Chinese and Caucasians. Neuroepidemiology 23:13–22
Chan DKY, Mok V, Ng PW et al (2008) PARK2 mutations and clinical features in a Chinese population with early onset Parkinson’s disease. J Neural Transm doi 10.1007/s00702-007-0011-6
Di Fonzo A, Wu-Chou YH, Lu CS et al (2006) A common missense variant in the LRRK2 gene, Gly2385Arg, associated with parkinson’s diseae risk in Taiwan. Neurogenetics 7:133–138
Funayama M, Li Y, Tomiyama H et al (2007) Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population. NeuroReport 18:273–275
Fung HC, Chen CM, Hardy J, Singleton AB, Wu YR (2006) A common genetic factor for Parkinson’s disease in ethnic Chinese population in Taiwan. BMC Neurol 6:47
Gilks WP, Abou-Sleiman PM, Gandhi S et al (2005) A common LRRK2 mutation in idiopathic Parkinson’s disease. Lancet 365(9457):415–416
Lu C, Simons E, Wu-Chou Y et al (2005) The I2012T, G2019S, and I2020T mutations are rare in Taiwanese patients with sporadic Parkinson’s disease. Parkinsonism and related disorders 11(8):521–522. NM_004562.1 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=83722281&from=121&to=7704&view=gbwithparts
Paisan-Ruiz C, Jain S, Evans EW et al (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease. Neuron 44(4):595–600
Tan EK, Zhao Y, Skipper L et al (2007) The LRRK2 Gly2385Arg variant is associated with Parkinson’s disease: genetic and functional evidence. Hum Genet 120:857–863
Taylor JP, Mata IF, Farrer MJ (2006) LRRK2: a common pathway for parkinsonism, pathogenesis and prevention? Trends Mol Med 12:76–82
Zimprich A, Biskup S, Leitner P et al (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44(4):601–607
Acknowledgments
We are indebted to the valuable support and advice from Prof. Richard Kay. Ethical standards: Ethics application were applied for and obtained by the Chinese University of Hong Kong. Informed consents were obtained from all participants.
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Chan, D.K.Y., Ng, P.W., Mok, V. et al. LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients. J Neural Transm 115, 1275–1277 (2008). https://doi.org/10.1007/s00702-008-0065-0
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DOI: https://doi.org/10.1007/s00702-008-0065-0