Abstract
Nifedipine (NIF), as one of the dihydropyridine calcium channel blockers, is widely used in the treatment of hypertension. However, misuse or ingestion of NIF can result in serious health issues such as myocardial infarction, arrhythmia, stroke, and even death. It is essential to design a reliable and sensitive detection method to monitor NIF. In this work, an innovative molecularly imprinted polymer dual-emission fluorescent sensor (CDs@PDA-MIPs) strategy was successfully designed for sensitive detection of NIF. The fluorescent intensity of the probe decreased with increasing NIF concentration, showing a satisfactory linear relationship within the range 1.0 × 10−6 M ~ 5.0 × 10−3 M. The LOD of NIF was 9.38 × 10−7 M (S/N = 3) in fluorescence detection. The application of the CDs@PDA-MIPs in actual samples such as urine and Qiangli Dingxuan tablets has been verified, with recovery ranging from 97.8 to 102.8% for NIF. Therefore, the fluorescent probe demonstrates great potential as a sensing system for detecting NIF.
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Sakellari D, Vouros I D, Aristodemou E et al (2005) Tetracycline fibers as an adjunct in the treatment of nifedipine-induced gingival enlargement. J Periodont 76:1034–1039. https://doi.org/10.1902/jop.2005.76.6.1034
Yamamoto H, Takayasu T, Nosaka M et al (2017) Fatal acute intoxication of accidentally ingested nifedipine in an infant - a case report. Leg Med (Tokyo) 24:12–18. https://doi.org/10.1016/j.legalmed.2016.11.002
Fami MJ, Ho NT, Mason CM (1998) Another report of adverse reactions to immediate release nifedipine. Pharmacotherapy 18:1133–1135. https://doi.org/10.1002/j.1875-9114.1998.tb03945.x
Yuan Y, Chen N, Wang L et al (2022) Rapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy. Anal Sci 38:359–368. https://doi.org/10.2116/analsci.21P148
Pan X, Zhou S, Fu Q et al (2013) Determination of nifedipine in dog plasma by high-performance liquid chromatography with tandem mass spectrometric detection. Biomed Chromatogr 28:1036–1040. https://doi.org/10.1002/bmc.3113
Sheng Y, Huang Z, Chen Y et al (2022) Facile high-quantum-yield sulfur-quantum-dot-based photoluminescent probe for nifedipine detection. Anal Bioanal Chem 414:7675–7681. https://doi.org/10.1007/s00216-022-04297-9
Peng J, Zhuge W, Huang Y et al (2019) UV-light photoelectrochemical sensor based on the copper tetraamino-phthalocyanine-modified ITO electrode for the detection of nifedipine in drugs and human serum. Bull Korean Chem Soc 40:214–219. https://doi.org/10.1002/bkcs.11667
Babulal S M, Chen T W, Akilarasan M et al (2022) One-pot synthesis of hetero-structured binary metal oxide electrocatalyst for the potential detection of nifedipine in biological and environmental samples. Mater Today Chem 26. https://doi.org/10.1016/j.mtchem.2022.101132
Rajendran S, UshaVipinachandran V, Badagoppam Haroon KH et al (2022) A comprehensive review on multi-colored emissive carbon dots as fluorescent probes for the detection of pharmaceutical drugs in water. Anal Methods 14:4263–4291. https://doi.org/10.1039/d2ay01288j
Ehtesabi H, Kalji SO (2024) Carbon nanomaterials for sweat-based sensors: a review. Mikrochim Acta 191:77. https://doi.org/10.1007/s00604-023-06162-7
Yan F, Hou Y, Yi C et al (2022) Carbon dots modified/prepared by supramolecular host molecules and their potential applications: a review. Anal Chim Acta 1232:340475. https://doi.org/10.1016/j.aca.2022.340475
Cui H, Yang J, Lu H et al (2022) Near-infrared carbon dots for cell imaging and detecting ciprofloxacin by label-free fluorescence sensor based on aptamer. Microchim Acta 189. https://doi.org/10.1007/s00604-022-05273-x
Liu C, Lin X, Liao J et al (2024) Carbon dots-based dopamine sensors: recent advances and challenges. Chin Chem Lett. https://doi.org/10.1016/j.cclet.2024.109598
Zor E, Mollarasouli F, Karadurmus L et al (2024) Carbon dots in the detection of pathogenic bacteria and viruses. Crit Rev Anal Chem 54:219–246. https://doi.org/10.1080/10408347.2022.2072168
Munusamy S, Mandlimath TR, Swetha P et al (2023) Nitrogen-doped carbon dots: recent developments in its fluorescent sensor applications. Environ Res 231:116046. https://doi.org/10.1016/j.envres.2023.116046
Huang Q, Lin X, Chen D et al (2022) Carbon Dots/α-Fe2O3-Fe3O4 nanocomposite: efficient synthesis and application as a novel electrochemical aptasensor for the ultrasensitive determination of aflatoxin B1. Food Chem 373:131415. https://doi.org/10.1016/j.foodchem.2021.131415
Zhou X, Pang Y, Wang Y et al (2023) Colorimetric and fluorescence dual-mode pH sensor based on nitrogen-doped carbon dots and its diverse applications. Mikrochim Acta 190:478. https://doi.org/10.1007/s00604-023-06064-8
Huang X, Song J, Yung BC et al (2018) Ratiometric optical nanoprobes enable accurate molecular detection and imaging. Chem Soc Rev 47:2873–2920. https://doi.org/10.1039/c7cs00612h
Cui H, Lu H, Yang J et al (2022) A significant fluorescent aptamer sensor based on carbon dots and graphene oxide for highly selective detection of progesterone. J Fluoresc 32:927–936. https://doi.org/10.1007/s10895-022-02896-4
Wen Y, Sun D, Zhang Y et al (2023) Molecular imprinting-based ratiometric fluorescence sensors for environmental and food analysis. Analyst 148:3971–3985. https://doi.org/10.1039/d3an00483j
He Y, Wang T, Cao J et al (2023) Molecular imprinting electrochemiluminescence sensor based on nitrogen-doped carbon quantum dots/Ru(bpy)3@SiO2 for the determination of citrinin. Mikrochim Acta 190:155. https://doi.org/10.1007/s00604-023-05735-w
Zhang T, Long D, Gu X et al (2022) A dual-recognition MIP-ECL sensor based on boric acid functional carbon dots for detection of dopamine. Mikrochim Acta 189:389. https://doi.org/10.1007/s00604-022-05483-3
Ranjbari S, Mohammadinejad A, Johnston T P et al (2023) Molecularly-imprinted polymers for the separation and detection of curcumin. Eur Polym J 189. https://doi.org/10.1016/j.eurpolymj.2023.111916
Shi T, Liu T, Zhang J et al (2023) A test strip constructed by molecular imprinting for ratiometric fluorescence with ultra-low limit of detection for selective monitoring of Sudan I in chili powder. Microchim Acta 190:263. https://doi.org/10.1007/s00604-023-05825-9
Nie Y, Liu Y, Su X et al (2019) Nitrogen-rich quantum dots-based fluorescence molecularly imprinted paper strip for p-nitroaniline detection. Microchem J 148:162–168. https://doi.org/10.1016/j.microc.2019.04.080
Yan J, Fu Q, Zhang S et al (2022) A sensitive ratiometric fluorescent sensor based on carbon dots and CdTe quantum dots for visual detection of biogenic amines in food samples. Spectroc Acta Pt. A-Molec Biomolec Spectr. 282. https://doi.org/10.1016/j.saa.2022.121706
Liu Y, Cao N, Gui W et al (2018) Nitrogen-doped graphene quantum dots-based fluorescence molecularly imprinted sensor for thiacloprid detection. Talanta 183:339–344. https://doi.org/10.1016/j.talanta.2018.01.063
Shao Y, Wang P, Zheng R et al (2023) Preparation of molecularly imprinted ratiometric fluorescence sensor for visual detection of tetrabromobisphenol A in water samples. Microchim Acta 190:161. https://doi.org/10.1007/s00604-023-05745-8
Pan L, Sun S, Zhang L et al (2016) Near-infrared emissive carbon dots for two-photon fluorescence bioimaging. Nanoscale 8:17350–17356. https://doi.org/10.1039/c6nr05878g
Pirot SM, Omer KM, Alshatteri AH et al (2023) Dual-template molecularly surface imprinted polymer on fluorescent metal-organic frameworks functionalized with carbon dots for ascorbic acid and uric acid detection. Spectrochim Acta A Mol Biomol Spectrosc 291:122340. https://doi.org/10.1016/j.saa.2023.122340
Bhogal S, Mohiuddin I, Kumar S et al (2022) Self-polymerized polydopamine-imprinted layer-coated carbon dots as a fluorescent sensor for selective and sensitive detection of 17β-oestradiol. Sci Total Environ 847. https://doi.org/10.1016/j.scitotenv.2022.157356
Han L, Liu T, Cui D et al (2022) Quantitative detection of captopril in urine by smartphone-assisted ratiometric fluorescence sensing platform. Spectrochim Acta A Mol Biomol Spectrosc 280:121562. https://doi.org/10.1016/j.saa.2022.121562
Zhai X, Cao Y, Sun W et al (2022) Core-shell composite N-doped-Co-MOF@polydopamine decorated with Ag nanoparticles for nonenzymatic glucose sensors. J Electroanal Chem 918. https://doi.org/10.1016/j.jelechem.2022.116491
Li J, Ma M, Zhang C et al (2020) Synthesis of a molecularly imprinted polymer using MOF-74(Ni) as matrix for selective recognition of lysozyme. Anal Bioanal Chem 412:7227–7236. https://doi.org/10.1007/s00216-020-02855-7
Gao P, Huang Z, Tan J et al (2022) Efficient conversion of elemental sulfur to robust ultrabright fluorescent sulfur quantum dots using sulfur-ethylenediamine precursor. Acs Sustainable Chem Eng 10:4634–4641. https://doi.org/10.1021/acssuschemeng.2c00036
Qian S, Qiao L, Xu W et al (2019) An inner filter effect-based near-infrared probe for the ultrasensitive detection of tetracyclines and quinolones. Talanta 194:598–603. https://doi.org/10.1016/j.talanta.2018.10.097
Omer SOBA, K M, (2022) Selectivity enhancement for uric acid detection via in situ preparation of blue emissive carbon dots entrapped in chromium metal-organic frameworks. ACS Omega 7:16576–16583. https://doi.org/10.1021/acsomega.2c00790
Yang J, Liu H, Huang Y et al (2023) One-step hydrothermal synthesis of near-infrared emission carbon quantum dots as fluorescence aptamer sensor for cortisol sensing and imaging. Talanta 260. https://doi.org/10.1016/j.talanta.2023.124637
Wang CX, Chen D, Yang YS et al (2021) Synthesis of multi-color fluorine and nitrogen co-doped graphene quantum dots for use in tetracycline detection, colorful solid fluorescent ink, and film. J Colloid Interface Sci 602:689–698. https://doi.org/10.1016/j.jcis.2021.06.062
Long P, Feng YY, Cao C et al (2018) Self-protective room-temperature phosphorescence of fluorine and nitrogen codoped carbon dots. Adv Funct Mater 28:10. https://doi.org/10.1002/adfm.201800791
Yang S, Peng L, Sun DT et al (2019) A new post-synthetic polymerization strategy makes metal-organic frameworks more stable. Chem Sci 10:4542–4549. https://doi.org/10.1039/c9sc00135b
Shahriyar SM, Lau-Cam CA (2000) A simple HPLC method with spectrophotometric detection for the simultaneous assay of nifedipine and verapamil in rat plasma. J Liq Chromatogr Relat Technol 23:1253–1265. https://doi.org/10.1081/jlc-100100412
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This work was financially supported by the National Natural Science Foundation of China (No. 22274096).
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Hao Liu: conceptualization; methodology; formal analysis; investigation; data curation; writing—original draft; writing—review and editing. Xuyuan Sun: resources. Zhengyuan Dai: resources. Ying Wang: resources. Li Li: supervision, writing—review and editing. Jie Fan: supervision, writing—review and editing. Yaping Ding: funding acquisition, supervision, writing—review and editing.
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Liu, H., Sun, X., Dai, Z. et al. A new three-dimensional (3D) molecularly imprinted polymer fluoroprobe based on green–red dual-emission signals of carbon quantum dots and self-polymerization of dopamine (CDs@PDA-MIPs) for sensitive detection of nifedipine. Microchim Acta 191, 332 (2024). https://doi.org/10.1007/s00604-024-06407-z
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DOI: https://doi.org/10.1007/s00604-024-06407-z