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Defective zirconium/titanium bimetallic metal–organic framework as a highly selective and sensitive electrochemical aptasensor for deoxynivalenol determination in foodstuffs

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Abstract

An electrochemical aptsensor for deoxynivalenol determination was successfully designed and constructed based on a defective bimetallic organic framework (denoted as ZrTi-MOF). The high porosity, large specific surface area, several structural defects, mixed metal clusters, and rich functionality of ZrTi-MOF markedly enhanced its electrochemical activity and facilitated the aptamer immobilization. As a result, the ZrTi-MOF–based aptasensor shows high sensitivity to detect deoxynivalenol via specific recognition between aptamer and deoxynivalenol, as well as the formation of aptamer-deoxynivalenol complex. On this basis, the developed ZrTi-MOF–based impedimetric aptasensor showed a low detection limit of 0.24 fg mL−1 for deoxynivalenol determination in the deoxynivalenol concentration range 1 fg mL−1– 1 ng mL−1 under optimized conditions, which also exhibited satisfactory selectivity, stability, reproducibility, and regenerability. Furthermore, determination of deoxynivalenol was achieved in bread and wheat flour samples via the developed ZrTi-MOF–based deoxynivalenol aptasensor. The result from this study showed that the ZrTi-MOF–based electrochemical aptasensor could become a promising strategy for detecting deoxynivalenol in foodstuffs in the future.

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Acknowledgements

The authors would like to thank the Henan Provincial Science and Technology Research Project, China (Nos. 212102210203 and 222102310153) and Xinxiang City Science and Technology Research Project, China (No. GG2021002).

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Authors and Affiliations

  1. School of Material Science and Engineering, Henan Normal University, Xinxiang, 453007, People’s Republic of China

    Mengmeng Kang

  2. College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou, 450001, People’s Republic of China

    Shunjiang Huang, Mengfei Wang, Minghua Wang & Zhihong Zhang

  3. Department of Chemistry, Faculty of Natural and Applied Sciences, Lead City University, Ibadan, Nigeria

    Olayinka Oderinde

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Mengmeng Kang: Investigation, writing — original draft, writing — review and editing, funding acquisition, data collection and analysis. Shunjiang Huang: Investigation, data collection and analysis. Mengfei Wang: Investigation, data collection and analysis. Olayinka Oderinde: Writing — review and editing. Minghua Wang: Formal analysis, writing — review and editing, funding acquisition. Zhihong Zhang: Investigation, methodology, formal analysis; supervision.

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Kang, M., Huang, S., Wang, M. et al. Defective zirconium/titanium bimetallic metal–organic framework as a highly selective and sensitive electrochemical aptasensor for deoxynivalenol determination in foodstuffs. Microchim Acta 190, 358 (2023). https://doi.org/10.1007/s00604-023-05935-4

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