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Slice-layer COFs-aerogel: a regenerative dispersive solid-phase extraction adsorbent for determination of ultra-trace quinolone antibiotics

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Abstract

A novel type of three-dimensional network structure, covalent organic frameworks (COFs) aerogel, was fabricated and applied to dispersive solid-phase extraction (dSPE) of quinolone antibiotics (QAs). Density functional theory (DFT) was applied to investigate the possible interaction mechanism and results confirmed that the strong adsorption affinity is attributed to the intralayer hydrogen bonds and π-π interaction. Furthermore, a sensitive analytical method based on COFs-aerogel for determining quinolone antibiotics residues in water and honey samples was developed and HPLC-MS/MS was used for sample detection and quantification. Under the optimal conditions, COFs-aerogel exhibited a wide linearity (0.1–500 ng∙L−1), low limits of detection (0.02–0.06 ng∙L−1), and good precision (RSD ˂ 10%) for selected QAs. A preliminary practical application of the developed method was proved by the efficient detection of quinolone antibiotics in water and food samples with good recoveries (68.2–104% and 64.0–100% for water and honey samples, respectively). Combining the experimental data with theoretical calculation, results illustrated that COFs-aerogel holds a great potential to capture contaminants and address environmental and food safety issues.

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Funding

This work is supported by the National Key Research and Development Program of China (2021YFA0910403), National Natural Science Foundation of China (No. 21972102), Jiangsu Laboratory for Biochemical Sensing and Biochip, and Jiangsu Key Laboratory for Micro and Nano Heat Fluid Flow Technology and Energy Application, Natural Science Foundation of Suzhou University of Science and Technology (No. 332114410).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215011, People’s Republic of China

    Qiulin Li, Feng Chen & Chunxian Guo

  2. China Fire and Rescue Institute, Beijing, 102200, People’s Republic of China

    Simin Zhu

  3. School of Material and Chemical Engineering, Bengbu University, Bengbu, 233000, People’s Republic of China

    Fang Wu

  4. Collaborative Innovation Center of Water Treatment Technology & Material, Suzhou University of Science and Technology, Suzhou, 215011, People’s Republic of China

    Chunxian Guo

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  1. Qiulin Li
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Supplementary information

ESM 1

Table S1 LC-MS/MS MRM data acquisition method. Table S2 Experimental domain and response surface design matrix for the optimization of the extraction step. Table S3 Parameters of kinetics. Table S4 Parameters of analytical performances. Figure S1 Nitrogen sorption isotherm profile of COFs-aerogel. Figure S2 (A) XPS survey spectrum of the surface of TAPB-DMTP-COFs; (B) XPS spectrum of the O 1s on the TAPB-DMTP-COFs. Figure S3 Response surfaces by BBD for the recovery based on a plot of adsorbent mass versus pH. Figure S4 (A) Typical chromatograms of selected analytes in the surface water sample and spiked sample with 100 ng/L; (B) Cyclic adsorption capacities of COFs-aerogel for the adsorption of QAs. Figure S5 The storage life time of COFs-aerogel (DOCX 2842 kb)

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Li, Q., Zhu, S., Wu, F. et al. Slice-layer COFs-aerogel: a regenerative dispersive solid-phase extraction adsorbent for determination of ultra-trace quinolone antibiotics. Microchim Acta 190, 369 (2023). https://doi.org/10.1007/s00604-023-05925-6

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