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Can Nonpenetrating Vascular Closure Staples and Hepatocyte Growth Factor Prevent Intimal Hyperplasia Following ePTFE Grafting of the Carotid Artery in Rabbits?

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Abstract.

Abstract.

Purpose:

To evaluate whether nonpenetrating vascular closure staples (VCS) and hepatocyte growth factor (HGF) can effectively prevent anastomotic intimal hyperplasia.

Methods:

An expanded polytetrafluoroethylene graft, 2 mm in diameter, was implanted in the common carotid artery of rabbits divided into three experimental groups. In the control group, distal anastomosis was performed with interrupted suturing; in the VCS group, clips were applied along the lateral suture line after the placement of stay sutures; and in the VCS + HGF group, the same anastomotic technique was performed as in the VCS group, followed by the administration of the HGF for 4 days.

Results:

The time taken to complete the anastomosis was significantly less in both the VCS groups than in the control group (P < 0.0001). On postoperative day (POD) 28, the patency rate was significantly lower (P < 0.05) in the VCS group (42.9%) than in the control group (100%), but the rate in the VCS + HGF group (100%) was the same as that in the control group. Intimal thickness was significantly less in the control group than in either the VCS or VCS + HGF groups (P < 0.05). The percentage of area stenosis was significantly less (P < 0.01) in the control group than in the VCS group.

Conclusion:

The VCS clip failed to suppress intimal thickness or reduce the percentage of stenosis at the anastomotic site.

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Received: July 13, 2001 / Accepted: November 20, 2001

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Akita, M., Takenaka, H., Harada, M. et al. Can Nonpenetrating Vascular Closure Staples and Hepatocyte Growth Factor Prevent Intimal Hyperplasia Following ePTFE Grafting of the Carotid Artery in Rabbits?. Surg Today 32, 618–622 (2002). https://doi.org/10.1007/s005950200111

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  • DOI: https://doi.org/10.1007/s005950200111

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