Skip to main content

Advertisement

SpringerLink
Log in

Benign multicystic mesothelioma with concurrent colonic adenocarcinoma: a report of two cases

  • Case Report
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Benign multicystic mesothelioma (BMM) is a rare tumoral lesion of the peritoneum often discovered incidentally upon surgery, laparoscopy, or radiographical imaging in females of childbearing age. The etiology and question as to whether these lesions occur via a neoplastic or reactive process still remain unknown. In this report, we present two cases of BMM detected in females with concurrent colonic adenocarcinoma arising in the ileocecal region. The tumors were present in the serosa surrounding the colonic adenocarcinoma in one case, and in the omentum in the other case, which grossly mimicked peritoneal seeding of carcinoma. An immunohistochemical analysis revealed that the cells lining the cystic spaces in both lesions were positive for keratin and calretinin, confirming their mesothelial origin. To the best of our knowledge, these cases represent the first documented examples of multicystic mesothelioma concurrent with colonic adenocarcinoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Abbreviations

BMM:

Benign multicystic mesothelioma

CEA:

Carcinoembryonic antigen

References

  1. Mennemeyer R, Smith M. Multicystic, peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer. 1979;44:692–8.

    Article  CAS  PubMed  Google Scholar 

  2. Ross MJ, Welch WR, Scully RE. Multilocular peritoneal inclusion cysts (so-called cystic mesotheliomas). Cancer. 1989;64:1336–46.

    Article  CAS  PubMed  Google Scholar 

  3. Sawh RN, Malpica A, Deavers MT, Liu J, Silva EG. Benign cystic mesothelioma of the peritoneum: a clinicopathologic study of 17 cases and immunohistochemical analysis of estrogen and progesterone receptor status. Hum Pathol. 2003;34:369–74.

    Article  CAS  PubMed  Google Scholar 

  4. Daya D, McCaughey WT. Pathology of the peritoneum: a review of selected topics. Semin Diagn Pathol. 1991;8:277–89.

    CAS  PubMed  Google Scholar 

  5. Moore JH Jr, Crum CP, Chandler JG, Feldman PS. Benign cystic mesothelioma. Cancer. 1980;45:2395–9.

    Article  PubMed  Google Scholar 

  6. Weiss SW, Tavassoli FA. Multicystic mesothelioma. An analysis of pathologic findings and biologic behavior in 37 cases. Am J Surg Pathol. 1988;12:737–46.

    Article  CAS  PubMed  Google Scholar 

  7. Gonzalez-Crussi F, Sotelo-Avila C, deMello DE. Primary peritoneal, omental, and mesenteric tumors in childhood. Semin Diagn Pathol. 1986;3:122–37.

    CAS  PubMed  Google Scholar 

  8. Terry NE, Fowler CL. Benign cystic mesothelioma in a child. J Pediatr Surg. 2009;44:e9–11.

    Article  PubMed  Google Scholar 

  9. Ball NJ, Urbanski SJ, Green FH, Kieser T. Pleural multicystic mesothelial proliferation. The so-called multicystic mesothelioma. Am J Surg Pathol. 1990;14:375–8.

    Article  CAS  PubMed  Google Scholar 

  10. Groisman GM, Kerner H. Multicystic mesothelioma with endometriosis. Acta Obstet Gynecol Scand. 1992;71:642–4.

    Article  CAS  PubMed  Google Scholar 

  11. McFadden DE, Clement PB. Peritoneal inclusion cysts with mural mesothelial proliferation. A clinicopathological analysis of six cases. Am J Surg Pathol. 1986;10:844–54.

    Article  CAS  PubMed  Google Scholar 

  12. Pollack CV Jr, Jorden RC. Benign cystic mesothelioma presenting as acute abdominal pain in a young woman. J Emerg Med. 1991;9(Suppl 1):21–5.

    Article  PubMed  Google Scholar 

  13. Gonzalez-Moreno S, Yan H, Alcorn KW, Sugarbaker PH. Malignant transformation of “benign” cystic mesothelioma of the peritoneum. J Surg Oncol. 2002;79:243–51.

    Article  PubMed  Google Scholar 

  14. Urbanczyk K, Skotniczny K, Kucinski J, Friediger J. Mesothelial inclusion cysts (so-called benign cystic mesothelioma)—a clinicopathological analysis of six cases. Pol J Pathol. 2005;56:81–7.

    PubMed  Google Scholar 

  15. Safioleas MC, Constantinos K, Michael S, Konstantinos G, Constantinos S, Alkiviadis K. Benign multicystic peritoneal mesothelioma: a case report and review of the literature. World J Gastroenterol. 2006;12:5739–42.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Hasteh F, Lin GY, Weidner N, Michael CW. The use of immunohistochemistry to distinguish reactive mesothelial cells from malignant mesothelioma in cytologic effusions. Cancer Cytopathol. 2010;118(2):90–6.

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

Neither of the authors has any conflict of interest to declare.

Author information

Authors and Affiliations

  1. Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, D.C., USA

    Anwar Husain

  2. Department of Pathology, Georgetown University Hospital, 3900 Reservoir Road, N.W., Washington, D.C., 20007, USA

    Metin Ozdemirli

Authors
  1. Anwar Husain
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Metin Ozdemirli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Metin Ozdemirli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Husain, A., Ozdemirli, M. Benign multicystic mesothelioma with concurrent colonic adenocarcinoma: a report of two cases. Surg Today 42, 978–982 (2012). https://doi.org/10.1007/s00595-011-0099-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-011-0099-z

Keywords

Search

Navigation