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Changes in the activities of semicarbazide-sensitive amine oxidase in inferior mesenteric artery segments and in serum of patients with type 2 diabetes

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Abstract

This study aimed to evaluate the semicarbazide-sensitive amine oxidase (SSAO) activity in human arterial tissues and in serum of patients with type 2 diabetes. The SSAO activity, with 14C-benzylamine as substrate, was measured in homogenates of human inferior mesenteric arteries obtained at surgery, from 10 patients with type 2 diabetes and 16 non-diabetic patients and in the serum of 39 patients with type 2 diabetes and 40 non-diabetic control patients. The SSAO activity in the homogenates of vascular tissue was significantly lower in the diabetics than in the non-diabetics (P = 0.001). The SSAO activity in the serum of patients with type 2 diabetes was higher when compared with control group (P = 0.0001). In conclusion, the SSAO activity increased in the serum and decreased in the arterial tissue. These findings suggest damage in the vascular tissue and support the hypothesis that serum SSAO may be a useful biochemical marker for diabetes.

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Acknowledgments

This work was included in CEF research group and was supported by the FCT (SFRH/BD/23606/2005)—Portugal.

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Authors and Affiliations

  1. Laboratory of Pharmacology, Faculty of Pharmacy, Coimbra University, 3000-548, Coimbra, Portugal

    Sandra Fernanda Nunes, Isabel Vitoria Figueiredo & Maria Margarida Caramona

  2. Portuguese Oncology Institute of Coimbra, Coimbra, Portugal

    João Santos Pereira

  3. São José Laboratory, Coimbra, Portugal

    Paulo João Soares

  4. Department of Pharmacology, University of Cambridge, Cambridge, UK

    Brian Callingham

Authors
  1. Sandra Fernanda Nunes
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  2. Isabel Vitoria Figueiredo
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  3. João Santos Pereira
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  4. Paulo João Soares
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  5. Maria Margarida Caramona
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  6. Brian Callingham
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Corresponding author

Correspondence to Maria Margarida Caramona.

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Nunes, S.F., Figueiredo, I.V., Pereira, J.S. et al. Changes in the activities of semicarbazide-sensitive amine oxidase in inferior mesenteric artery segments and in serum of patients with type 2 diabetes. Acta Diabetol 47, 179–182 (2010). https://doi.org/10.1007/s00592-009-0174-8

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  • DOI: https://doi.org/10.1007/s00592-009-0174-8

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