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Can hydroxyapatite charged collagen sponge help reduce perioperative blood loss in adolescent idiopathic scoliosis surgery? Preliminary results in 68 patients

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Abstract

Purpose

Patient blood management has been recently emphasized to avoid perioperative blood transfusion in AIS surgery. Hydroxyapatite charged collagen sponge (HCS) is a bone substitute material made of collagen and ceramized hydroxyapatite, with associated haemostatic properties. The goal of this study was to assess the impact of HCS in the perioperative blood loss in AIS surgery.

Methods

After IRB approval, all AIS patients undergoing primary correction were prospectively included over a 15-month period. Patients receiving HCS at the end of the procedure were compared to a control group (matched for age, gender, and fusion levels) without any haemostatic agent or bone substitute. The same perioperative blood saving strategies were used in both groups. Two subfascial drains were used for 48 h in all patients. Perioperative blood loss and transfusion rates were analysed.

Results

A total of 34 patients were included in each group. No difference in drainage volume was observed at day 1, but the reduction was statistically different at day 3 (1135 mL [800–1640] versus 930 [480–1510], p = 0.028, 0.63 ml/Kg/h [0.4–0.92] versus 0.46 [0.29–0.7], p = 0.042). Multivariate analysis found that the use of HCS was associated with a decrease in the postoperative blood loss (OR = 1.17 [1.10–1.25]). The transfusion rate was lower in the HCS group [0 (0% vs. 3(8.8%), p = 0.076)]. No infection occurred, and no complication was reported.

Conclusion

With 27% reduction in drain volume, hydroxyapatite charged collagen sponge can be considered as a blood salving strategy in AIS surgery. The role of the biomaterial in fusion rate still needs to be further assessed.

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Funding

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Authors and Affiliations

  1. Department of Anesthesia and Intensive Care, Robert Debré Hospital, 48 boulevard Sérurier, 75019, Paris, France

    Florence Julien-Marsollier

  2. Université de Paris, Paris, France

    Florence Julien-Marsollier, Adele Happiette & Brice Ilharreborde

  3. UFR Sciences Pharmaceutiques, Université de Bordeaux, Bordeaux, France

    Leo Penisson

  4. Department of Orthopedic Surgery, Robert Debré Hospital, 48 boulevard Sérurier, 75019, Paris, France

    Adele Happiette & Brice Ilharreborde

Authors
  1. Florence Julien-Marsollier
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  2. Leo Penisson
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  3. Adele Happiette
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  4. Brice Ilharreborde
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Contributions

FJ-M contributed to study design, statistical analysis and performed measurements and manuscript preparation. Consent to participate and to publish was obtained from OK; LP and AH contributed to study design and performed measurements and manuscript preparation; BI contributed to study design and performed measurements, statistical analysis and manuscript preparation.

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Correspondence to Florence Julien-Marsollier.

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Conflict of interest

Brice Ilharreborde reports work as a consultant for Implanet, ZimmerBiomet and Medtronics.

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Yes (comite d evaluationd’ethique des projets de l’hopital ROBERT Debre).

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Julien-Marsollier, F., Penisson, L., Happiette, A. et al. Can hydroxyapatite charged collagen sponge help reduce perioperative blood loss in adolescent idiopathic scoliosis surgery? Preliminary results in 68 patients. Eur Spine J 32, 883–888 (2023). https://doi.org/10.1007/s00586-022-07512-4

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  • DOI: https://doi.org/10.1007/s00586-022-07512-4

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