Abstract
Hemangiosarcoma is a type of malignant vascular tumour that commonly affects the canines and has a very poor prognosis. Five dogs affected with cutaneous hemangiosarcoma were presented to Referral Veterinary Polyclinic, Indian Veterinary Research Institute, Izatnagar, over a 6-month period. All of the cases were subjected to thoracic radiography and intra-abdominal ultrasonography to rule out metastasis. The tumour mass was surgically excised in all the five animals. The cases were diagnosed as hemangiosarcoma on the basis of histopathology and immunohistochemistry. Two of the animals received chemotherapy using either vincristine or doxorubicin after surgical excision. The post-operative survival period was found to be slightly higher in the cases that received combined surgical excision and chemotherapy. The main aim of managing such cases should be to prolong the life of the animal by combining various treatment modalities like surgical excision, chemotherapy, immunotherapy and radiation therapy. This paper concludes that the combined use of surgical excision and chemotherapy can be superior to surgical excision alone in prolonging the life of dogs suffering from a cutaneous form of hemangiosarcoma.
This is a preview of subscription content, log in via an institution to check access.
References
Batschinski K, Nobre A, Vargas-Mendez E, Tedardi MV, Cirillo J, Cestari G, Dagli MLZ (2018) Canine visceral hemangiosarcoma treated with surgery alone or surgery and doxorubicin: 37 cases (2005-2014). Can Vet J 59(9):967–972
Bravo R, Frank R, Blundell PA, Macdonald-Bravo H (1987) Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 326:515–517
Brown NO, Patnaik AK, MacEwen EG (1985) Canine hemangiosarcoma: retrospective analysis of 104 cases. J Am Vet Med Assoc 186(1):56–58
Clifford CA, Mackin AJ, Henry CJ (2000) Treatment of canine hemangiosarcoma: 2000 and beyond. J Vet Intern Med 14(5):479–485
Dervisis NG, Dominguez PA, Newman RG, Cadile CD, Kitchell BE (2011) Treatment with DAV for advanced-stage hemangiosarcoma in dogs. J Am Anim Hosp Assoc 47(3):170–178
Fosmire SP, Dickerson EB, Scott AM, Bianco SR, Pettengill MJ, Meylemans H, Padilla M, Frazer-Abel AA, Akhtar N, Getzy DM, Wojcieszyn J (2004) Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Lab Investig 84(5):562–572
Gorden BH, Kim JH, Sarver AL, Frantz AM, Breen M, Lindblad-Toh K, O’Brien TD, Sharkey LC, Modiano JF, Dickerson EB (2014) Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization. Am J Pathol 184(4):985–995
Karabağli G, Düzgün O, Yildar E, Erdoğan Ö, Gürel A (2011) A hemangiosarcoma case in a dog. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 37(2):161–165
Kim JH, Graef A, Dickerson E, Modiano J (2015) Pathobiology of hemangiosarcoma in dogs: research advances and future perspectives. Vet Sci 2(4):388–405
Lamerato-Kozicki AR, Helm KM, Jubala CM, Cutter GC, Modiano JF (2006) Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol 34(7):870–878
Nóbrega DF, Sehaber VF, Madureira R, Bracarense APFRL (2019) Canine cutaneous haemangiosarcoma: biomarkers and survival. J Comp Pathol 166:87–96
Ogilvie GK, Powers BE, Mallinckrodt CH, Withrow SJ (1996) Surgery and doxorubicin in dogs with hemangiosarcoma. J Vet Intern Med 10(6):379–384
Schultheiss PC (2004) A retrospective study of visceral and nonvisceral hemangiosarcoma and hemangiomas in domestic animals. J Vet Diagn Investig 16(6):522–526
Smetana K, Gyorkey F, Chan PK, Tan E, Busch H (1983) Proliferating cell nuclear antigen (PCNA) and human malignant tumor nucleolar antigens (HMTNA) in nucleoli of human hematological malignancies. Blut 46(3):133–141
U’ren LW, Biller BJ, Elmslie RE, Thamm DH, Dow SW (2007) Evaluation of a novel tumor vaccine in dogs with hemangiosarcoma. J Vet Intern Med 21(1):113–120
Ward H, Fox LE, Calderwood-Mays MB, Hammer AS, Couto CG (1994) Cutaneous hemangiosarcoma in 25 dogs: a retrospective study. J Vet Intern Med 8(5):345–348
Weisse C, Soares N, Beal MW, Steffey MA, Drobatz KJ, Henry CJ (2005) Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy: 23 cases (1986–2000). J Am Vet Med Assoc 226(4):575–579
Wendelburg KM, Price LL, Burgess KE, Lyons JA, Lew FH, Berg J (2015) Survival time of dogs with splenic hemangiosarcoma treated by splenectomy with or without adjuvant chemotherapy: 208 cases (2001–2012). J Am Vet Med Assoc 247(4):393–403
Wiley JL, Rook KA, Clifford CA, Gregor TP, Sorenmo KU (2010) Efficacy of doxorubicin-based chemotherapy for non-resectable canine subcutaneous haemangiosarcoma. Vet Comp Oncol 8(3):221–233
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
This article does not contain any studies with human or animal participants performed by any of the authors. All protocols followed were as per the guidelines from the standard textbooks in Veterinary Medicine and Surgery and were ethical.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sharun, K., Basha, M.A., Shah, M.A. et al. Clinical management of cutaneous hemangiosarcoma in canines: a review of five cases. Comp Clin Pathol 28, 1815–1822 (2019). https://doi.org/10.1007/s00580-019-03039-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00580-019-03039-1