Abstract
Introduction
The end-expiratory occlusion test (EEOT) may predict the response to fluid administration in patients undergoing lung-protective ventilation, but arterial catheter insertion is necessary to evaluate changes in stroke volume (SV). The peripheral perfusion index is a potential noninvasive alternative to evaluate SV. The aim of this study is to investigate whether changes in perfusion index during an intraoperative EEOT can predict the response to fluid administration in patients undergoing lung-protective ventilation (tidal volume 7 ml/kg predicted body weight).
Methods
Forty-one elective surgical patients were enrolled. The SV and perfusion index were recorded before (baseline), during a 40-s EEOT and after volume expansion (250 ml of lactated Ringer’s solution over 10 min). Patients with an increase in SV greater than 10% after volume expansion were defined as responders. ΔPI (change in perfusion index between baseline and 20 (ΔPI20) or 40 s (ΔPI40) after the beginning of EEOT were calculated using: ΔPI20 (%) = [(PI at 20 s after EEOT beginning − PIbaseline)/PIbaseline] × 100, ΔPI40 (%) = [(PI at 40 s after EEO beginning − PIbaseline)/PIbaseline] × 100).
Results
Sixteen patients were responders, and 25 were non-responders. The area under the receiver operating characteristics curves generated for ΔPI20 and ΔPI40 to predict response to a fluid challenge were 0.561 (95% CI 0.374–0.749) and 0.688 (95% CI 0.523–0.852), respectively.
Conclusion
Changes in perfusion index during intraoperative EEOT in patients undergoing lung-protective ventilation (7 ml/kg) were unable to predict the response to fluid administration.
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Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Change history
02 December 2022
A Correction to this paper has been published: https://doi.org/10.1007/s00540-022-03147-3
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YI and MS contributed to the conception and design of the study. YI and MS analyzed the data and wrote the manuscript. YI, YO, KY and TN helped with the data collection. MS and AL revised the manuscript critically. All authors read and approved the final manuscript.
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This study was approved by the institutional Review Board (S20-042). Participants were obtained written informed consent.
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Iizuka, Y., Sanui, M., Otsuka, Y. et al. Changes in peripheral perfusion index during intraoperative end-expiratory occlusion tests do not predict the response to fluid administration in patients undergoing lung protective ventilation. J Anesth 35, 837–843 (2021). https://doi.org/10.1007/s00540-021-02988-8
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DOI: https://doi.org/10.1007/s00540-021-02988-8