Skip to main content
Log in

Neighbourhood component analysis and deep feature-based diagnosis model for middle ear otoscope images

  • Original Article
  • Published:
Neural Computing and Applications Aims and scope Submit manuscript

Abstract

Otitis media (OM), known as inflammation of the middle ear, is a condition especially seen in children. To carry out a definitive diagnosis of the discomfort that manifests itself with various symptoms such as pain in the ear, fever, and discharge, the eardrum in the middle ear should be examined by a specialist. In this study, a convolution neural network was used for feature extraction from middle ear otoscope images to diagnose different types of OM. These features were extracted using AlexNet, VGG-16, GoogLeNet, ResNet-50 models. The deep features extracted from these models were combined into a new deep feature vector. This feature vector consisting of 4000 deep features was examined, and the most relevant 222 deep features were selected from this large feature set by using the neighbourhood component analysis. In this case, the number of features was decreased and a more effective feature set was obtained. In the next stage of this experimental study, this new feature set was applied as the input to the support vector machine. As a result of the experimental study, an accuracy rate of 79.02% was achieved. The results point out that the use of deep features in detecting OM provides efficient results, and the proposed approach is beneficial in reducing the number of deep features as well as achieving better classification results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

Data availability

The dataset used in this study can be accessed via a website: http://www.ctganalysis.com/Category/otitis-media.

References

  1. van den Broek MFL, De Boeck I, Kiekens F, Boudewyns A, Vanderveken OM, Lebeer S (2019) Translating recent microbiome insights in otitis media into probiotic strategies. Clin Microbiol Rev 32(4):e00010-18. https://doi.org/10.1128/CMR.00010-18

    Article  Google Scholar 

  2. Duygu E, Şevik Eliçora S (2020) Our experience on the management of acute mastoiditis in pediatric acute otitis media patients. Int J Pediatr Otorhinolaryngol 138:110372. https://doi.org/10.1016/j.ijporl.2020.110372

    Article  Google Scholar 

  3. van Uum RT et al (2020) Improving pain management in childhood acute otitis media in general practice: a cluster randomised controlled trial of a GP-targeted educational intervention. Br J Gen Pract. https://doi.org/10.3399/bjgp20X712589

    Article  Google Scholar 

  4. Kono M et al (2021) Features predicting treatment failure in pediatric acute otitis media. J Infect Chemother 27(1):19–25. https://doi.org/10.1016/j.jiac.2020.08.003

    Article  Google Scholar 

  5. Barron CL, Kamel-Abusalha LB, Sethia R, Goodman SD, Elmaraghy CA, Bakaletz LO (2020) Identification of essential biofilm proteins in middle ear fluids of otitis media with effusion patients. Laryngoscope 130(3):806–811. https://doi.org/10.1002/lary.28011

    Article  Google Scholar 

  6. Čvorović L et al (2020) Is otitis media with effusion associated with Samter’s triad a new nosological entity? A preliminary report on inflammatory mediator production. Eur Arch Oto-Rhino-Laryngology. https://doi.org/10.1007/s00405-020-06276-1

    Article  Google Scholar 

  7. Isaacson G, Griswold S (2020) Differentiating acute otitis media from otitis media with effusion. Vis J Emerg Med 21:100891. https://doi.org/10.1016/j.visj.2020.100891

    Article  Google Scholar 

  8. Subramaniam V, Ashkar A, Rai S (2020) Cochlear dysfunction in chronic otitis media and its determinants. Iran J Otorhinolaryngol 32(109):79–84. https://doi.org/10.22038/ijorl.2019.35045.2158

    Article  Google Scholar 

  9. Maharjan M, Phuyal S, Shrestha M, Bajracharya R (2020) Chronic otitis media and subsequent hearing loss in children from the himalayan region residing in buddhist monastic schools of Nepal. J Otol. https://doi.org/10.1016/j.joto.2020.09.001

    Article  Google Scholar 

  10. Pontefract B, Nevers M, Fleming-Dutra KE, Hersh A, Samore M, Madaras-Kelly K (2019) Diagnosis and antibiotic management of otitis media and otitis externa in United States veterans. Open Forum Infect Dis. https://doi.org/10.1093/ofid/ofz432

    Article  Google Scholar 

  11. Schwartz RH, (2008) “CHAPTER 32—Otitis Externa and Malignant Otitis Externa,” S. S. B. T.-P. and P. of P. I. D. (Third E. Long, Ed. Edinburgh: W.B. Saunders, pp 230–232

  12. Zafer C (2020) Fusing fine-tuned deep features for recognizing different tympanic membranes. Biocybern Biomed Eng 40(1):40–51. https://doi.org/10.1016/j.bbe.2019.11.001

    Article  Google Scholar 

  13. Goggin LS, Eikelboom RH, Atlas MD (2007) Clinical decision support systems and computer-aided diagnosis in otology. Otolaryngol. Neck Surg. 136(4_suppl):s21–s26. https://doi.org/10.1016/j.otohns.2007.01.028

    Article  Google Scholar 

  14. Myburgh HC, Van Zijl WH, Swanepoel D, Hellström S, Laurent C (2016) EBioMedicine otitis media diagnosis for developing countries using tympanic membrane image-analysis. EBioMedicine 5:156–160

    Article  Google Scholar 

  15. Anupama Kuruvilla1 AHJK, Li2 J, Yeomans1 PH, Quelhas3 P, Shaikh4 N, (2012) “Otitis Media Vocabulary and Grammar,” Media, pp 2845–2848

  16. Huang YK, Huang CP (2018) “A depth-first search algorithm based otoscope application for real-time otitis media image interpretation.” Parallel Distrib Comput Appl Technol PDCAT Proc 2017:170–175. https://doi.org/10.1109/PDCAT.2017.00036

    Article  Google Scholar 

  17. Başaran E,Şengür A, Cömert Z, Budak Ü, Çelık Y, Velappan S, (2019) “Normal and Acute Tympanic Membrane Diagnosis based on Gray Level Co-Occurrence Matrix and Artificial Neural Networks,” in 2019 international artificial intelligence and data processing symposium (IDAP), pp 1–6, https://doi.org/10.1109/IDAP.2019.8875973

  18. Shie CK, Chang HT, Fan FC, Chen CJ, Fang TY, Wang PC, (2014) “A hybrid feature-based segmentation and classification system for the computer aided self-diagnosis of otitis media,” 2014 36th Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. EMBC 2014, pp 4655–4658, https://doi.org/10.1109/EMBC.2014.6944662

  19. Myburgh HC, Jose S, Swanepoel DW, Laurent C (2018) Towards low cost automated smartphone- and cloud-based otitis media diagnosis. Biomed Signal Process Control 39:34–52. https://doi.org/10.1016/j.bspc.2017.07.015

    Article  Google Scholar 

  20. Basaran E, Comert Z, Sengur A, Budak A, Celik Y, Togacar M, (2019) “Chronic Tympanic Membrane Diagnosis based on Deep Convolutional Neural Network,” https://doi.org/10.1109/UBMK.2019.8907070

  21. Başaran E, Cömert Z, Şengur A, Budak Ü, Çelik Y, Toğaçar M, (2020) “Normal ve Kronik Hastalıklı Orta Kulak İmgelerinin Evrişimsel Sinir Ağları Yöntemiyle Tespit Edilmesi,” Türkiye Bilişim Vakfı Bilgi. Bilim. ve Mühendisliği Derg., 13(1), pp 1–10, Accessed: Apr. 26, 2020. [Online]. Available: http://dergipark.org.tr/tr/pub/tbbmd/issue/53711/657649

  22. Cömert Z (2019) Otitis media için evrişimsel sinir ağlarına dayalı entegre bir tanı sistemi. Bitlis Eren Üniversitesi Fen Bilim Derg 8(4):1498–1511. https://doi.org/10.17798/bitlisfen.600636

    Article  Google Scholar 

  23. Başaran E, Cömert Z, Çelik Y (2020) Convolutional neural network approach for automatic tympanic membrane detection and classification. Biomed Signal Process Control 56:101734. https://doi.org/10.1016/J.BSPC.2019.101734

    Article  Google Scholar 

  24. Binol H et al (2020) SelectStitch: automated frame segmentation and stitching to create composite images from otoscope video clips. Appl Sci 10(17):5894. https://doi.org/10.3390/app10175894

    Article  Google Scholar 

  25. Tetila EC et al (2020) Detection and classification of soybean pests using deep learning with UAV images. Comput Electron Agric 179:105836. https://doi.org/10.1016/j.compag.2020.105836

    Article  Google Scholar 

  26. Toğaçar M, Ergen B, Cömert Z (2020) COVID-19 detection using deep learning models to exploit Social Mimic Optimization and structured chest X-ray images using fuzzy color and stacking approaches. Comput Biol Med 121:103805. https://doi.org/10.1016/j.compbiomed.2020.103805

    Article  Google Scholar 

  27. Afshar P, Mohammadi A, Plataniotis KN, (2018) “Brain Tumor Type Classification via Capsule Networks,” Accessed: Apr. 07, 2019. [Online]. Available: http://arxiv.org/abs/1802.10200

  28. Toğaçar M, Ergen B, Cömert Z (2019) Detection of lung cancer on chest CT images using minimum redundancy maximum relevance feature selection method with convolutional neural networks. Biocybern Biomed Eng. https://doi.org/10.1016/J.BBE.2019.11.004

    Article  Google Scholar 

  29. A. Ş. Ümit Budak, Ömer Faruk Alçin, Muzaffer Aslan, (2018) “Optic Disc Detection in Retinal Images via Faster Regional Convolutional Neural Networks,” pp 3–5

  30. Guo Y, Budak Ü, Vespa LJ, Khorasani E, Şengür A (2018) A retinal vessel detection approach using convolution neural network with reinforcement sample learning strategy. Measurement 125:586–591. https://doi.org/10.1016/j.measurement.2018.05.003

    Article  Google Scholar 

  31. Qiao Y, Truman M, Sukkarieh S (2019) Cattle segmentation and contour extraction based on Mask R-CNN for precision livestock farming. Comput Electron Agric 165:104958. https://doi.org/10.1016/j.compag.2019.104958

    Article  Google Scholar 

  32. Roberto GF, Lumini A, Neves LA, Do Nascimento MZ (2021) Fractal Neural Network: a new ensemble of fractal geometry and convolutional neural networks for the classification of histology images. Expert Syst Appl 166:114103. https://doi.org/10.1016/j.eswa.2020.114103

    Article  Google Scholar 

  33. Krizhevsky A, Sutskever I, Hinton GE, (2012) “ImageNet Classification with Deep Convolutional Neural Networks,” In: proceedings of the 25th international conference on neural information processing systems - Volume 1, pp 1097–1105

  34. Szegedy C et al., (2015) “Going deeper with convolutions,” In: 2015 IEEE conference on computer vision and pattern recognition (CVPR), pp 1–9, https://doi.org/10.1109/CVPR.2015.7298594

  35. He K, Zhang X, Ren S, Sun J, (2016) “Deep residual learning for image recognition,” In: proceedings of the IEEE conference on computer vision and pattern recognition, pp 770–778, https://doi.org/10.1109/CVPR.2016.90

  36. Ayyıldız H, Arslan Tuncer S (2020) Determination of the effect of red blood cell parameters in the discrimination of iron deficiency anemia and beta thalassemia via neighborhood component analysis feature selection-based machine learning. Chemom Intell Lab Syst 196:103886. https://doi.org/10.1016/j.chemolab.2019.103886

    Article  Google Scholar 

  37. Ladha L, Deepa T (2011) Feature selection methods and algorithms. Int J Comput Sci Eng 3(5):1787–1797

    Google Scholar 

  38. Guyon I, Elisseeff A (2003) An introduction to variable and feature selection. J Mach Learn Res 3:1157–1182

    MATH  Google Scholar 

  39. Yaman O (2021) An automated faults classification method based on binary pattern and neighborhood component analysis using induction motor. Measurement 168:108323. https://doi.org/10.1016/j.measurement.2020.108323

    Article  Google Scholar 

  40. Tuncer T, Dogan S, Acharya UR (2021) Automated accurate speech emotion recognition system using twine shuffle pattern and iterative neighborhood component analysis techniques. Knowledge-Based Syst 211:106547. https://doi.org/10.1016/j.knosys.2020.106547

    Article  Google Scholar 

  41. Yang W, Wang K, Zuo W (2012) Neighborhood component feature selection for high-dimensional data. JCP 7(1):161–168

    Google Scholar 

  42. Iqbal S, Khan MUG, Saba T, Rehman A (2017) Computer-assisted brain tumor type discrimination using magnetic resonance imaging features. Biomed Eng Lett 8(1):5–28. https://doi.org/10.1007/s13534-017-0050-3

    Article  Google Scholar 

  43. Vapnik V (1998) “The support vector method of function estimation”, in nonlinear modeling. Springer, Cham, pp 55–85

    Google Scholar 

  44. Toğaçar M, Ergen B, Cömert Z (2020) Classification of flower species by using features extracted from the intersection of feature selection methods in convolutional neural network models. Measurement 158:107703. https://doi.org/10.1016/J.MEASUREMENT.2020.107703

    Article  Google Scholar 

  45. Amyar A, Modzelewski R, Li H, Ruan S (2020) Multi-task deep learning based CT imaging analysis for COVID-19 pneumonia: classification and segmentation. Comput Biol Med 126:104037. https://doi.org/10.1016/j.compbiomed.2020.104037

    Article  Google Scholar 

  46. Kermany DS et al (2018) Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell 172(5):1122-1131.e9. https://doi.org/10.1016/j.cell.2018.02.010

    Article  Google Scholar 

  47. Li S, Song W, Qin H, Hao A (2018) Deep variance network: an iterative, improved CNN framework for unbalanced training datasets. Pattern Recognit 81:294–308. https://doi.org/10.1016/J.PATCOG.2018.03.035

    Article  Google Scholar 

  48. Marom T, Bobrow M, Eviatar E, Oron Y, Ovnat S (2017) Adherence to acute otitis media diagnosis and treatment guidelines among Israeli otolaryngologists. Int J Pediatric Otorhinolaryngol 95:63–68

    Article  Google Scholar 

  49. Binol H et al., (2020) “Decision fusion on image analysis and tympanometry to detect eardrum abnormalities,” In Medical Imaging 2020: Computer-Aided Diagnosis, 2020, 11314, pp 375–382, doi: https://doi.org/10.1117/12.2549394

  50. Uçar M, Akyol K, Atila Ü, Uçar E (2021) Classification of different tympanic membrane conditions using fused deep hypercolumn features and bidirectional LSTM. IRBM. https://doi.org/10.1016/j.irbm.2021.01.001

    Article  Google Scholar 

Download references

Funding

There is no funding source for this article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Erdal Başaran.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest related to this paper.

Ethical approval

This article does not contain any data or other information from studies or experimentation, with the involvement of human or animal subjects.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Başaran, E., Cömert, Z. & Çelik, Y. Neighbourhood component analysis and deep feature-based diagnosis model for middle ear otoscope images. Neural Comput & Applic 34, 6027–6038 (2022). https://doi.org/10.1007/s00521-021-06810-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00521-021-06810-0

Keywords

Navigation