Abstract
Introduction
Over the past few years, new chemotherapy agents have emerged, and several are oral. This review attempts to highlight the challenges associated with the interactions between food and chemotherapy, both oral and intravenous.
Discussion
It provides tentative answers to three questions. Does oral chemotherapy bestow adverse effects derived from its oral administration, as related to food or taste? What instruction should health care providers give patients about food ingestion prior to prescribing oral chemotherapy? How should we counsel patients about eating before intravenous chemotherapy?
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References
Weingart SN, Brown E, Bach PB, Eng K, Johnson SA, Kuzel TM, Langbaum TS, Leedy RD, Muller RJ, Newcomer LN, O’Brien S, Reinke D, Rubino M, Saltz L, Walters RS (2007) NCCN Task Force report: oral chemotherapy. J Natl Compr Canc Netw 6:S1–S14
Winkeljohn DL (2007) Oral chemotherapy medications: the need for the nurse’s touch. Clin J Oncol Nurs 11(6):793–796. doi:10.1188/07.CJON.793-796
Smith SD, Cairns NU, Sturgeon JK, Lansky SB (1981) Poor drug compliance in an adolescent with leukemia. Am J Pediatr Hematol Oncol 3:297–300
Festa RS, Tamaraoff MH, Chasalow F, Lanzkowsky P (1992) Therapeutic adherence to oral medication regimens by adolescents with cancer. J Pediatr 120:807–811. doi:10.1016/S0022-3476(05)80256-2
Reigner B, Verweij J, Dirix L, Cassidy J, Twelves C, Allman D, Weidekamm E, Roos B, Banken L, Utoh M, Osterwalder B (1998) Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients. Clin Cancer Res 4:941–948
Koch KM, Reddy NJ, Cohen RB, Lewis NL, Whitehead B, Mackay K, Stead A, Beelen AP, Lewis LD (2009) Effects of food on the relative bioavailability of lapatinib in cancer patients. J Clin Oncol 27:1191–1196. doi:10.1200/JCO.2008.18.3285
Benmebarek M, Devaud C, Gex-Fabry M et al (2004) Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone. Clin Pharmacol Ther 76:55–63. doi:10.1016/j.clpt.2004.03.007
Farkas D, Greenblatt DJ (2008) Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 4:381–393. doi:10.1517/17425255.4.4.381
Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD (2008) Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A 105(24):8215–8220. doi:10.1073/pnas.0708100105
Johnson JB, John S, Laub DR (2009) Pretreatment with alternate dry modified fast will permit higher dose and frequency of cancer chemotherapy and better cure rates. Med Hypotheses 72:381–382. doi:10.1016/j.mehy.2008.07.064
Kozubik A, Pospisil M (1982) Protective effect of intermittent fasting on the mortality of gamma-irradiated mice. Stahlentherapie 158(12):734–738
Dirks AJ, Leeuwenburgh C (2006) Caloric restriction in humans: pitfalls and health concerns. Mech Ageing Dev 12(1):1–7. doi:10.1016/j.mad.2005.09.001
Couzin J (2008) Can fasting blunt chemotherapy’s debilitating side effects? Science 321:1146–1147 (www.sciencemag.org)
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Jatoi, A. Cancer chemotherapy: with or without food?. Support Care Cancer 18 (Suppl 2), 13–16 (2010). https://doi.org/10.1007/s00520-009-0666-7
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DOI: https://doi.org/10.1007/s00520-009-0666-7