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Blood pressure parameters affecting ventricular repolarization in obese children

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Abstract

Background

Ventricular repolarization (VR) increases the risk of sudden cardiac death due to ventricular arrhythmia. We aimed to evaluate the blood pressure (BP) parameters affecting VR in obese children.

Methods

Obese (BMI ≥ 95p) and healthy children ≥ 120 cm between January 2017 and June 2019 were included. Demographic and laboratory data, peripheral and central BPs evaluated by a device capable of ambulatory blood pressure monitoring (ABPM), and pulse wave analysis were assessed. Electrocardiographic ventricular repolarization indices, left ventricular mass index (LVMI), and relative wall thickness (RWT) were calculated.

Results

A total of 52 obese and 41 control patients were included. Uric acid, triglyceride, total cholesterol, LDL, and ALT values, systolic and diastolic office BPs, 24-h, daytime and nighttime systolic and mean arterial BPs, daytime diastolic BP SDS levels, daytime and nighttime systolic loads, daytime diastolic load, 24-h, daytime and nighttime central systolic and diastolic BPs, and pulse wave velocity values were significantly higher, whereas 24-h, daytime and nighttime AIx@75 were similar between the groups. fT4 levels of obese cases were significantly lower. QTcd and Tp-ed were higher in obese patients. Although RWT was higher in obese cases, LVMI values and cardiac geometry classifications were similar. The independent factors affecting VR in obese cases were younger age and higher diastolic load at night (B =  − 2.83, p = 0.010; B = 0.257, p = 0.007, respectively).

Conclusion

Obese patients have higher peripheral and central BP, arterial stiffness, and higher VR indices that develop before an increase in LVMI. It would be useful to prevent obesity from an early age and follow up nighttime diastolic load to control VR associated sudden cardiac death in obese children.

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Data Availability

Data of this study is available as an SPSS form.

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Funding

This work was supported by İzmir Katip Çelebi University Scientific Research Projects Coordination Unit (Project Number: 2016-GAP-TIPF-0028).

Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Nephrology, Izmir Katip Çelebi University, Izmir, Turkey

    Belde Kasap Demir & Eren Soyaltın

  2. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey

    Belde Kasap Demir, Eren Soyaltın, Seçil Arslansoyu Çamlar, Demet Alaygut & Fatma Mutlubaş

  3. Department of Pediatrics, Division of Nephrology, Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkey

    Caner Alparslan

  4. Department of Pediatrics, Division of Cardiology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey

    Tülay Demircan & Cem Karadeniz

  5. Department of Pediatrics, Division of Nephrology, University of Health Sciences Izmir Medical Faculty, Izmir, Turkey

    Seçil Arslansoyu Çamlar, Demet Alaygut & Fatma Mutlubaş

  6. Department of Pediatrics, Division of Neurology, Başkent University, Ankara, Turkey

    Elif Perihan Öncel

  7. Department of Pediatrics, Division of Nephrology, Istanbul Medipol University, Istanbul, Turkey

    Önder Yavaşcan

  8. Department of Pediatrics, Division of Endocrinology, İzmir Katip Çelebi University, İzmir, Turkey

    Bumin Nuri Dündar

  9. Department of Pediatrics, Division of Endocrinology, University of Health Sciences Izmir Tepecik Training and Research Hospital, Izmir, Turkey

    Bumin Nuri Dündar

  10. Department of Pediatrics, Division of Cardiology, Izmir Katip Çelebi University, İzmir, Turkey

    Cem Karadeniz

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  1. Belde Kasap Demir
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Correspondence to Belde Kasap Demir.

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Kasap Demir, B., Soyaltın, E., Alparslan, C. et al. Blood pressure parameters affecting ventricular repolarization in obese children. Pediatr Nephrol 38, 3359–3367 (2023). https://doi.org/10.1007/s00467-023-05971-5

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