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Increased cystatin C concentration in urine of nephrotic children

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Abstract

The aim of this study was to evaluate changes in urine and plasma concentrations of cystatin C in children with a relapse of the idiopathic nephrotic syndrome (INS). The study group comprised 12 children with INS with proteinuria and 12 children in an 8-week remission, both treated with steroids. Twelve healthy children served as controls. Cystatin C was detectable in the urine of children with proteinuria. The study suggests that massive proteinuria may influence renal cystatin C handling.

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Authors and Affiliations

  1. Department of Nephrology and Dialysis, Polish Mother’s Memorial Hospital Research Institute, 281/289 Rzgowska Street, 93–338 Łódź, Poland

    Marcin Tkaczyk & Michał Nowicki

  2. Immunochemistry Laboratory, Polish Mother’s Memorial Hospital Research Institute, Łódź, Poland

    Jolanta Lukamowicz

Authors
  1. Marcin Tkaczyk
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  2. Michał Nowicki
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  3. Jolanta Lukamowicz
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Correspondence to Marcin Tkaczyk.

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Tkaczyk, M., Nowicki, M. & Lukamowicz, J. Increased cystatin C concentration in urine of nephrotic children. Pediatr Nephrol 19, 1278–1280 (2004). https://doi.org/10.1007/s00467-004-1566-1

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  • DOI: https://doi.org/10.1007/s00467-004-1566-1

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