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Near-infrared fluorescent solid material for visualizing indwelling devices implanted for medical use

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Abstract

Background

In clinical practice, various devices are implanted into the body for medical reasons. As X-ray fluoroscopy is necessary to visualize medical devices implanted into the body, the development of a less-invasive visualization method is highly desired. This study aimed to investigate the clinical applicability of our novel solid material that emits near-infrared fluorescence.

Methods

We developed a solid resin material that emits near-infrared fluorescence. This material incorporates a near-infrared fluorescent pigment, with quantum yield ≥ 20 times than that of indocyanine green. It can be sterilized for medical treatment. This resin material is designed to be molded into a catheter and inserted into the body with an endoscope clip. In this preclinical experiment using a swine model, the resin material was embedded into the body of the swine and visualized with a near-infrared fluorescence camera system.

Results

Endoscopic clips were placed in the mucosa of the stomach, esophagus, and large intestine, and the indwelling ureteral catheters were successfully visualized by near-infrared fluorescence laparoscopy.

Conclusions

We confirmed the tissue permeability of the fluorescence emitted by our novel near-infrared fluorescent material and the possibility of its clinical application. This material may allow visualization of devices embedded in the body.

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Funding

This work was supported by a Grant-in-Aid for Scientific Research, from the Japanese Society for the Promotion of Science (Grant Number JP19H04487).

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Authors and Affiliations

  1. Department of Thoracic Surgery, Kochi Medical School, Kochi University, Kohasu Oko, Nankoku, 783-8505, Japan

    Takashi Anayama, Kentaro Hirohashi, Ryohei Miyazaki, Marino Yamamoto & Hironobu Okada

  2. Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan

    Takayuki Sato

  3. Department of Surgery II, Kochi Medical School, Nankoku, Japan

    Kazumasa Orihashi

  4. Center for Photodynamic Medicine, Kochi Medical School, Kochi University, Nankoku, Japan

    Keiji Inoue & Kazuhiro Hanazaki

  5. Cancer Treatment Center, Kochi Medical School Hospital, Nankoku, Japan

    Michiya Kobayashi

  6. Department of Surgery, International University of Health and Welfare Hospital, Nasushiobara, Japan

    Masashi Yoshida

Authors
  1. Takashi Anayama
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  2. Takayuki Sato
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  11. Kazuhiro Hanazaki
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Corresponding author

Correspondence to Takashi Anayama.

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Disclosures

Drs Takashi Anayama, Takayuki Sato, Kentaro Hirohashi, Ryohei Miyazaki, Marino Yamamoto, Hironobu Okada, Kazumasa Orihashi, Keiji Inoue, Michiya Kobayashi, Masashi Yoshida, and Kazuhiro Hanasaki have no conflicts of interest or financial ties to disclose.

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Anayama, T., Sato, T., Hirohashi, K. et al. Near-infrared fluorescent solid material for visualizing indwelling devices implanted for medical use. Surg Endosc 34, 4206–4213 (2020). https://doi.org/10.1007/s00464-020-07634-0

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  • DOI: https://doi.org/10.1007/s00464-020-07634-0

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