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Biological tissue adhesive for mesh-application in pigs: An experimental study

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Abstract

Background

Tissue damage during herniotomy may attribute to postoperative complications including chronic pain, bleeding and infection. Thus the aim of this study was to evaluate a due and simple operative procedure with intraperitoneal application of mesh with glue in an experimental model prior to use in humans.

Method

Laparoscopic insertion of a mesh was performed in three pigs. The meshes were fixed with a collagen glue. The pigs were sacrificed after 8 weeks and macroscopic and microscopic evaluation of the meshes, were performed.

Results

The intraperitoneal placed meshes did not migrate through the study period, and there was no sign of inflammation in surrounding tissue or adhesions around the meshes.

Conclusions

If these findings can be applied to human inguinal herniotomy, this may lead to significant fewer complications including development of acute and chronic pain, formation of seroma and infection. Furthermore the operation technique is very simple.

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Acknowledgments

Institute of Experimental Clinical Science, Skejby University Hospital, is acknowledged for their assistance in performing the surgery. Sofradim® Trévoux, France, is acknowledged for economic support for the animal studies.

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Authors and Affiliations

  1. Department of Surgery D, Glostrup University Hospital, Ndr. Ringvej, Glostrup, DK 2600, Denmark

    S. Schulze & V. B. Kristiansen

  2. Department of Pathology, Hvidovre University Hospital, Kettegaards Allé, Hvidovre, DK 2650, Denmark

    B. Fischer Hansen

  3. Department of Surgery D, Gentofte University Hospital, Niels Andersens Vej, Gentofte, DK 2820, Denmark

    J. Rosenberg

Authors
  1. S. Schulze
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  2. V. B. Kristiansen
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  3. B. Fischer Hansen
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  4. J. Rosenberg
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Correspondence to S. Schulze.

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Schulze, S., Kristiansen, V.B., Hansen, B.F. et al. Biological tissue adhesive for mesh-application in pigs: An experimental study. Surg Endosc 19, 342–344 (2005). https://doi.org/10.1007/s00464-004-9054-z

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  • DOI: https://doi.org/10.1007/s00464-004-9054-z

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