Abstract
The cdc6 mutants of Schizosaccharomyces pombe have been classified as being defective in progression through the G2 phase of the cell cycle. We cloned an S. pombe gene that could complement the temperature-sensitive growth of the cdc6-23 mutant. Unexpectedly, the cloned gene was allelic to pol3, which encodes the catalytic subunit of DNA polymerase δ. Integration mapping confirmed that cdc6 and pol3 are identical. The cdc6-23 mutant carries one amino acid substitution in the conserved N3 region of Pol3.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 17 October 1996 / Accepted: 19 November 1996
Rights and permissions
About this article
Cite this article
Iino, Y., Yamamoto, M. The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase δ. Mol Gen Genet 254, 93–97 (1997). https://doi.org/10.1007/s004380050395
Issue Date:
DOI: https://doi.org/10.1007/s004380050395