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Comparative genomic assessment of members of genus Tenacibaculum: an exploratory study

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Abstract

Tenacibaculosis is an ulcerative skin disorder that affects finfish. It is caused by members of the genus Tenacibaculum, resulting in eccentric behavioural changes, including anorexia, lethargy, and abnormal swimming patterns that often result in mortality. Currently, species suspected of causing fish mortality include T. ovolyticum, T. gallaicum, T. discolor, T. finnmarkense, T. mesophilum, T. soleae, T. dicentrarchi, and T. maritimum. However, pathogenic members and the mechanisms involved in disease causation, progression, and transmission are limited due to the inadequate sequencing efforts in the past decade. In this study, we use a comparative genomics approach to investigate the characteristic features of 26 publicly available genomes of Tenacibaculum and report our observations. We propose the reclassification of “T. litoreum HSC 22” to the singaporense species and assignment of “T. sp. 4G03” to the species discolor (species with quotation marks have not been appropriately named). We also report the co-occurrence of several antimicrobial resistance/virulence genes and genes private to a few members. Finally, we mine several non-B DNA forming regions, operons, tandem repeats, high-confidence putative effector proteins, and sortase that might play a pivotal role in bacterial evolution, transcription, and pathogenesis.

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Acknowledgements

The authors would like to thank Jamia Millia Islamia for providing computational and other support.

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  1. Computational Intelligence and Bioinformatics Laboratory, Department of Computer Science, Jamia Millia Islamia, New Delhi, 110025, India

    Rohit Satyam, Shaban Ahmad & Khalid Raza

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  1. Rohit Satyam
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Contributions

Conceptualization: RS and KR; data curation: RS; formal analysis: RS; methodology: RS; project administration: SA; supervision: KR; validation: RS; visualization: RS; roles/writing—original draft: RS; writing—review and editing: KR and SA.

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Correspondence to Khalid Raza.

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Satyam, R., Ahmad, S. & Raza, K. Comparative genomic assessment of members of genus Tenacibaculum: an exploratory study. Mol Genet Genomics 298, 979–993 (2023). https://doi.org/10.1007/s00438-023-02031-3

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